Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine
Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. Howev...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1516850/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841527845297324032 |
|---|---|
| author | Hongchao Wu Hongchao Wu Peipei Qiao Yunyu Chen Caihong Liu Ningning Huo Hangtian Ding Xiaojuan Wang Lulu Wang Xiangfeng Xi Yuxiu Liu Kegong Tian Kegong Tian |
| author_facet | Hongchao Wu Hongchao Wu Peipei Qiao Yunyu Chen Caihong Liu Ningning Huo Hangtian Ding Xiaojuan Wang Lulu Wang Xiangfeng Xi Yuxiu Liu Kegong Tian Kegong Tian |
| author_sort | Hongchao Wu |
| collection | DOAJ |
| description | Feline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination. |
| format | Article |
| id | doaj-art-a42e9a4803f842e49971007e3e9f92d2 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-a42e9a4803f842e49971007e3e9f92d22025-01-15T06:10:37ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15168501516850Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccineHongchao Wu0Hongchao Wu1Peipei Qiao2Yunyu Chen3Caihong Liu4Ningning Huo5Hangtian Ding6Xiaojuan Wang7Lulu Wang8Xiangfeng Xi9Yuxiu Liu10Kegong Tian11Kegong Tian12College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, ChinaNational Research Center for Veterinary Medicine, Luoyang, ChinaFeline herpesvirus 1 (FHV-1) is an important pathogen causing infectious rhinotracheitis in felids, mainly infecting the upper respiratory tract and conjunctiva. Multiple vaccines are available to prevent FHV-1 infection, and the antibody levels are always used to evaluate their effectiveness. However, the cellular immunity response following immunization in cats remains unclear. This study investigated the immune responses (humoral and cellular) in cats immunized with the FHV-1 modified live virus vaccine. The results indicated that vaccination significantly reduced clinical signs, and antibody levels, including virus-neutralizing (VN) antibodies and immunoglobulin G (IgG), in the vaccine group were higher than those in the control groups. Additionally, the vaccine significantly increased cytokine secretion, indicating Th1-type cellular immune responses in cats. Moreover, cellular immune-related indicators, such as CD8+ T cells, CD4+ T cells, and interferon-gamma levels, were inversely correlated with clinical signs post-challenge by FHV-1 in vaccinated cats, highlighting its crucial role in protecting cats against FHV-1 infection. In summary, this study demonstrated the importance of cellular immune responses in protecting cats from FHV-1 infection after vaccination.https://www.frontiersin.org/articles/10.3389/fvets.2024.1516850/fullfeline herpesvirus 1MLV vaccinecatscellular immune responsesIFNγ |
| spellingShingle | Hongchao Wu Hongchao Wu Peipei Qiao Yunyu Chen Caihong Liu Ningning Huo Hangtian Ding Xiaojuan Wang Lulu Wang Xiangfeng Xi Yuxiu Liu Kegong Tian Kegong Tian Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine Frontiers in Veterinary Science feline herpesvirus 1 MLV vaccine cats cellular immune responses IFNγ |
| title | Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| title_full | Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| title_fullStr | Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| title_full_unstemmed | Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| title_short | Cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| title_sort | cellular and humoral immune responses in cats vaccinated with feline herpesvirus 1 modified live virus vaccine |
| topic | feline herpesvirus 1 MLV vaccine cats cellular immune responses IFNγ |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1516850/full |
| work_keys_str_mv | AT hongchaowu cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT hongchaowu cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT peipeiqiao cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT yunyuchen cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT caihongliu cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT ningninghuo cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT hangtianding cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT xiaojuanwang cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT luluwang cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT xiangfengxi cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT yuxiuliu cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT kegongtian cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine AT kegongtian cellularandhumoralimmuneresponsesincatsvaccinatedwithfelineherpesvirus1modifiedlivevirusvaccine |