Decellularized extracellular matrix-based disease models for drug screening
In vitro drug screening endeavors to replicate cellular states closely resembling those encountered in vivo, thereby maximizing the fidelity of drug effects and responses within the body. Decellularized extracellular matrix (dECM)-based materials offer a more authentic milieu for crafting disease mo...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003417 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846123356625043456 |
|---|---|
| author | Zhoujiang Chen Ji Wang Ranjith Kumar Kankala Mingli Jiang Lianlin Long Wei Li Liang Zou Aizheng Chen Ya Liu |
| author_facet | Zhoujiang Chen Ji Wang Ranjith Kumar Kankala Mingli Jiang Lianlin Long Wei Li Liang Zou Aizheng Chen Ya Liu |
| author_sort | Zhoujiang Chen |
| collection | DOAJ |
| description | In vitro drug screening endeavors to replicate cellular states closely resembling those encountered in vivo, thereby maximizing the fidelity of drug effects and responses within the body. Decellularized extracellular matrix (dECM)-based materials offer a more authentic milieu for crafting disease models, faithfully emulating the extracellular components and structural complexities encountered by cells in vivo. This review discusses recent advancements in leveraging dECM-based materials as biomaterials for crafting cell models tailored for drug screening. Initially, we delineate the biological functionalities of diverse ECM components, shedding light on their potential influences on disease model construction. Further, we elucidate the decellularization techniques and methodologies for fabricating cell models utilizing dECM substrates. Then, the article delves into the research strides made in employing dECM-based models for drug screening across a spectrum of ailments, including tumors, as well as heart, liver, lung, and bone diseases. Finally, the review summarizes the bottlenecks, hurdles, and promising research trajectories associated with the dECM materials for drug screening, alongside their prospective applications in personalized medicine. Together, by encapsulating the contemporary research landscape surrounding dECM materials in cell model construction and drug screening, this review underscores the vast potential of dECM materials in drug assessment and personalized therapy. |
| format | Article |
| id | doaj-art-a409d9bc323a45c48f1e8e44e9491f0e |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-a409d9bc323a45c48f1e8e44e9491f0e2024-12-14T06:32:07ZengElsevierMaterials Today Bio2590-00642024-12-0129101280Decellularized extracellular matrix-based disease models for drug screeningZhoujiang Chen0Ji Wang1Ranjith Kumar Kankala2Mingli Jiang3Lianlin Long4Wei Li5Liang Zou6Aizheng Chen7Ya Liu8Institute for Advanced Study, Chengdu University, Chengdu, 610106, Sichuan, PR ChinaAffiliated Hospital & Clinical Medical College of Chengdu University, Chengdu University, Chengdu, 610106, Sichuan, PR ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, 361021, Fujian, PR ChinaSchool of Pharmacy, Zunyi Medical University, Zunyi, 563099, Guizhou, PR ChinaSchool of Pharmacy, Zunyi Medical University, Zunyi, 563099, Guizhou, PR ChinaAffiliated Hospital & Clinical Medical College of Chengdu University, Chengdu University, Chengdu, 610106, Sichuan, PR ChinaInstitute for Advanced Study, Chengdu University, Chengdu, 610106, Sichuan, PR ChinaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, 361021, Fujian, PR China; Corresponding author. Institute of Biomaterials and Tissue Engineering, Huaqiao University, NO. 668 Jimei Avenue, Xiamen, Fujian, 361021, PR China.Affiliated Hospital & Clinical Medical College of Chengdu University, Chengdu University, Chengdu, 610106, Sichuan, PR China; Corresponding author. Affiliated Hospital & Clinical Medical College of Chengdu University, Chengdu University, No. 2025 Chengluo Avenue, Chengdu, Sichuan, 610106, PR China.In vitro drug screening endeavors to replicate cellular states closely resembling those encountered in vivo, thereby maximizing the fidelity of drug effects and responses within the body. Decellularized extracellular matrix (dECM)-based materials offer a more authentic milieu for crafting disease models, faithfully emulating the extracellular components and structural complexities encountered by cells in vivo. This review discusses recent advancements in leveraging dECM-based materials as biomaterials for crafting cell models tailored for drug screening. Initially, we delineate the biological functionalities of diverse ECM components, shedding light on their potential influences on disease model construction. Further, we elucidate the decellularization techniques and methodologies for fabricating cell models utilizing dECM substrates. Then, the article delves into the research strides made in employing dECM-based models for drug screening across a spectrum of ailments, including tumors, as well as heart, liver, lung, and bone diseases. Finally, the review summarizes the bottlenecks, hurdles, and promising research trajectories associated with the dECM materials for drug screening, alongside their prospective applications in personalized medicine. Together, by encapsulating the contemporary research landscape surrounding dECM materials in cell model construction and drug screening, this review underscores the vast potential of dECM materials in drug assessment and personalized therapy.http://www.sciencedirect.com/science/article/pii/S2590006424003417Drug screeningExtracellular matrixCell modelsDecellularizationPersonalized medicine |
| spellingShingle | Zhoujiang Chen Ji Wang Ranjith Kumar Kankala Mingli Jiang Lianlin Long Wei Li Liang Zou Aizheng Chen Ya Liu Decellularized extracellular matrix-based disease models for drug screening Materials Today Bio Drug screening Extracellular matrix Cell models Decellularization Personalized medicine |
| title | Decellularized extracellular matrix-based disease models for drug screening |
| title_full | Decellularized extracellular matrix-based disease models for drug screening |
| title_fullStr | Decellularized extracellular matrix-based disease models for drug screening |
| title_full_unstemmed | Decellularized extracellular matrix-based disease models for drug screening |
| title_short | Decellularized extracellular matrix-based disease models for drug screening |
| title_sort | decellularized extracellular matrix based disease models for drug screening |
| topic | Drug screening Extracellular matrix Cell models Decellularization Personalized medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003417 |
| work_keys_str_mv | AT zhoujiangchen decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT jiwang decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT ranjithkumarkankala decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT minglijiang decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT lianlinlong decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT weili decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT liangzou decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT aizhengchen decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening AT yaliu decellularizedextracellularmatrixbaseddiseasemodelsfordrugscreening |