A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms

A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms

Abstract In humans, vasopressin AVP1BR receptor (hV1B) plays key roles in hypothalamic–pituitary–adrenal (HPA) axis regulation and social behavior. Three hV1B polymorphisms, rs35369693 (K65N), rs28632197 (R364H) and rs33990840 (G191R), have been related to psychiatric disorders with altered HPA axis...

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Bibliographic Details
Main Authors: Adrián Alacreu-Crespo, Emilie Olié, Maxime Manière, Jeremy Deverdun, Emmanuelle Lebars, Maithé Corbani, Gilles Guillon, Philippe Courtet
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neuroscience
Subjects:
Vasopressin
Vasopressin 1B receptor
Genetic polymorphism
Pharmacological signaling
Emotional processing
fMRI
Online Access:https://doi.org/10.1186/s12868-025-00963-7
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