Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals

Aseptic abscesses syndrome is a rare but increasingly recognized disease that falls within the spectrum of autoinflammatory disorders. Here, we describe the case of a patient who presented with abdominal pain and fever, along with multiple abdominal and extra-abdominal abscesses, in the absence of u...

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Main Authors: Federica Maria Ucci, Rossana Scrivo, Cristiano Alessandri, Fabrizio Conti, Roberta Priori
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454813/full
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author Federica Maria Ucci
Rossana Scrivo
Cristiano Alessandri
Fabrizio Conti
Roberta Priori
Roberta Priori
author_facet Federica Maria Ucci
Rossana Scrivo
Cristiano Alessandri
Fabrizio Conti
Roberta Priori
Roberta Priori
author_sort Federica Maria Ucci
collection DOAJ
description Aseptic abscesses syndrome is a rare but increasingly recognized disease that falls within the spectrum of autoinflammatory disorders. Here, we describe the case of a patient who presented with abdominal pain and fever, along with multiple abdominal and extra-abdominal abscesses, in the absence of underlying hematologic, autoimmune, infectious, or neoplastic conditions. Initially, the patient responded to glucocorticoids, but experienced several flares upon discontinuation, leading to the initiation of treatment with a TNFα inhibitor. After 5 years, an attempt to discontinue treatment resulted in a new flare of the disease. Remission was eventually achieved with a biosimilar TNFα inhibitor, albeit requiring shortened infusion intervals.
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institution Kabale University
issn 1664-3224
language English
publishDate 2024-12-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Immunology
spelling doaj-art-a3e4e51d1b7a4a1d8dc391619ed96a1f2024-12-03T05:10:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14548131454813Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervalsFederica Maria Ucci0Rossana Scrivo1Cristiano Alessandri2Fabrizio Conti3Roberta Priori4Roberta Priori5Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Rheumatology Unit, Sapienza University of Rome, Rome, ItalyDepartment of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Rheumatology Unit, Sapienza University of Rome, Rome, ItalyDepartment of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Rheumatology Unit, Sapienza University of Rome, Rome, ItalyDepartment of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Rheumatology Unit, Sapienza University of Rome, Rome, ItalyDepartment of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Rheumatology Unit, Sapienza University of Rome, Rome, ItalySaint Camillus International University of Health Science, UniCamillus, Rome, ItalyAseptic abscesses syndrome is a rare but increasingly recognized disease that falls within the spectrum of autoinflammatory disorders. Here, we describe the case of a patient who presented with abdominal pain and fever, along with multiple abdominal and extra-abdominal abscesses, in the absence of underlying hematologic, autoimmune, infectious, or neoplastic conditions. Initially, the patient responded to glucocorticoids, but experienced several flares upon discontinuation, leading to the initiation of treatment with a TNFα inhibitor. After 5 years, an attempt to discontinue treatment resulted in a new flare of the disease. Remission was eventually achieved with a biosimilar TNFα inhibitor, albeit requiring shortened infusion intervals.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454813/fullaseptic abscess syndromeautoinflammatory disorderTNFα-inhibitorbiosimilarnon-medical switch
spellingShingle Federica Maria Ucci
Rossana Scrivo
Cristiano Alessandri
Fabrizio Conti
Roberta Priori
Roberta Priori
Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
Frontiers in Immunology
aseptic abscess syndrome
autoinflammatory disorder
TNFα-inhibitor
biosimilar
non-medical switch
title Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
title_full Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
title_fullStr Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
title_full_unstemmed Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
title_short Aseptic abscess syndrome: a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
title_sort aseptic abscess syndrome a case report of a patient achieving remission with both infliximab originator and biosimilar administered at varied intervals
topic aseptic abscess syndrome
autoinflammatory disorder
TNFα-inhibitor
biosimilar
non-medical switch
url https://www.frontiersin.org/articles/10.3389/fimmu.2024.1454813/full
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