Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition typically characterized by fever and lymphadenopathy. The exact etiology remains unclear but is suspected to be associated with viral infections and autoimmune responses. This report presents the case of a 32-year-old Chinese male who...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519988/full |
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| author | Jing Ye Qian Yu Yan Chen Chunping Huang |
| author_facet | Jing Ye Qian Yu Yan Chen Chunping Huang |
| author_sort | Jing Ye |
| collection | DOAJ |
| description | Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition typically characterized by fever and lymphadenopathy. The exact etiology remains unclear but is suspected to be associated with viral infections and autoimmune responses. This report presents the case of a 32-year-old Chinese male who was admitted with recurrent high fever, lymphadenopathy, and hepatosplenomegaly. Initial treatment was ineffective, and a lymph node biopsy subsequently confirmed the diagnosis of KFD, with evidence of cytomegalovirus infection. Following treatment with corticosteroids, the patient’s symptoms improved rapidly, and no relapse was observed during follow-up after discharge. This case highlights the diagnostic challenges of KFD, particularly in distinguishing it from lymphoma and systemic lupus erythematosus. Accurate and timely diagnosis is crucial to avoid unnecessary treatments, and long-term follow-up is recommended to monitor for potential disease progression. |
| format | Article |
| id | doaj-art-a3de3251c3b94a65b9d82ce3e9b62caf |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a3de3251c3b94a65b9d82ce3e9b62caf2025-01-10T05:10:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15199881519988Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adultJing Ye0Qian Yu1Yan Chen2Chunping Huang3Department of General Practice, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Pathology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of General Practice, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of General Practice, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, ChinaKikuchi-Fujimoto disease (KFD) is a rare, self-limiting condition typically characterized by fever and lymphadenopathy. The exact etiology remains unclear but is suspected to be associated with viral infections and autoimmune responses. This report presents the case of a 32-year-old Chinese male who was admitted with recurrent high fever, lymphadenopathy, and hepatosplenomegaly. Initial treatment was ineffective, and a lymph node biopsy subsequently confirmed the diagnosis of KFD, with evidence of cytomegalovirus infection. Following treatment with corticosteroids, the patient’s symptoms improved rapidly, and no relapse was observed during follow-up after discharge. This case highlights the diagnostic challenges of KFD, particularly in distinguishing it from lymphoma and systemic lupus erythematosus. Accurate and timely diagnosis is crucial to avoid unnecessary treatments, and long-term follow-up is recommended to monitor for potential disease progression.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519988/fullKikuchi-Fujimoto diseaselymphadenopathyviral infectionsautoimmunedifferential diagnosis |
| spellingShingle | Jing Ye Qian Yu Yan Chen Chunping Huang Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult Frontiers in Immunology Kikuchi-Fujimoto disease lymphadenopathy viral infections autoimmune differential diagnosis |
| title | Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| title_full | Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| title_fullStr | Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| title_full_unstemmed | Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| title_short | Case report: Kikuchi-Fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| title_sort | case report kikuchi fujimoto disease presenting with persistent fever and widespread lymphadenopathy in a young adult |
| topic | Kikuchi-Fujimoto disease lymphadenopathy viral infections autoimmune differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519988/full |
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