Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing
Abstract Bioactive substance-integrated hydrogels have demonstrated efficacy in diabetic wound treatment. However, challenges remain in identifying naturally derived, multifunctional active substances capable of addressing the complex pathophysiology of wounds, as well as in tailoring hydrogels to e...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03666-7 |
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| author | Junyi Che Danqing Huang Yang Wang Guangtao Gao Yuanjin Zhao |
| author_facet | Junyi Che Danqing Huang Yang Wang Guangtao Gao Yuanjin Zhao |
| author_sort | Junyi Che |
| collection | DOAJ |
| description | Abstract Bioactive substance-integrated hydrogels have demonstrated efficacy in diabetic wound treatment. However, challenges remain in identifying naturally derived, multifunctional active substances capable of addressing the complex pathophysiology of wounds, as well as in tailoring hydrogels to enhance their suitability for wound applications. Here, we present a novel biological hydrogel microcarrier system by integrating Bletilla striata-derived nanoparticles (PdNPs) and polydopamine nanozymes (PDAs) into a hyaluronic acid-methacrylate (HAMA) hydrogel. PdNPs can polarize over-activated macrophages to an anti-inflammatory phenotype and restore fibroblast functionality. Meanwhile, PDAs act as potent reactive oxygen species (ROS) scavengers and protect fibroblasts from oxidative stress-induced apoptosis. When encapsulated into HAMA microcarriers, the PdNP + PDA@HAMA microcarriers significantly accelerate wound healing in a diabetic rat model. These outcomes demonstrate the therapeutic potential of our natural, multifunctional hydrogel microcarriers as a promising wound dressing platform for the treatment of chronic diabetic wounds. |
| format | Article |
| id | doaj-art-a3ddbe2b25a94be3a606b0fca1ed4e4a |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-a3ddbe2b25a94be3a606b0fca1ed4e4a2025-08-24T11:48:54ZengBMCJournal of Nanobiotechnology1477-31552025-08-0123111210.1186/s12951-025-03666-7Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healingJunyi Che0Danqing Huang1Yang Wang2Guangtao Gao3Yuanjin Zhao4Department of Rheumatology and Immunology, School of Biological Science and Medical Engineering, Nanjing Drum Tower Hospital, Southeast UniversityDepartment of Rheumatology and Immunology, School of Biological Science and Medical Engineering, Nanjing Drum Tower Hospital, Southeast UniversityDepartment of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineDepartment of Hematology, Nanjing Drum Tower HospitalDepartment of Rheumatology and Immunology, School of Biological Science and Medical Engineering, Nanjing Drum Tower Hospital, Southeast UniversityAbstract Bioactive substance-integrated hydrogels have demonstrated efficacy in diabetic wound treatment. However, challenges remain in identifying naturally derived, multifunctional active substances capable of addressing the complex pathophysiology of wounds, as well as in tailoring hydrogels to enhance their suitability for wound applications. Here, we present a novel biological hydrogel microcarrier system by integrating Bletilla striata-derived nanoparticles (PdNPs) and polydopamine nanozymes (PDAs) into a hyaluronic acid-methacrylate (HAMA) hydrogel. PdNPs can polarize over-activated macrophages to an anti-inflammatory phenotype and restore fibroblast functionality. Meanwhile, PDAs act as potent reactive oxygen species (ROS) scavengers and protect fibroblasts from oxidative stress-induced apoptosis. When encapsulated into HAMA microcarriers, the PdNP + PDA@HAMA microcarriers significantly accelerate wound healing in a diabetic rat model. These outcomes demonstrate the therapeutic potential of our natural, multifunctional hydrogel microcarriers as a promising wound dressing platform for the treatment of chronic diabetic wounds.https://doi.org/10.1186/s12951-025-03666-7Bletilla striataParticleNanozymeMicrofluidicsWound healing |
| spellingShingle | Junyi Che Danqing Huang Yang Wang Guangtao Gao Yuanjin Zhao Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing Journal of Nanobiotechnology Bletilla striata Particle Nanozyme Microfluidics Wound healing |
| title | Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| title_full | Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| title_fullStr | Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| title_full_unstemmed | Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| title_short | Natural multi-active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| title_sort | natural multi active nanoparticles integrated biological hydrogel microcarriers for wound healing |
| topic | Bletilla striata Particle Nanozyme Microfluidics Wound healing |
| url | https://doi.org/10.1186/s12951-025-03666-7 |
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