The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease
Alzheimer’s disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high costs, invasiveness, and limited accessibility restrict...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/15/1965 |
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| author | Vasileios Papaliagkas |
| author_facet | Vasileios Papaliagkas |
| author_sort | Vasileios Papaliagkas |
| collection | DOAJ |
| description | Alzheimer’s disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high costs, invasiveness, and limited accessibility restrict universal screening. Quantitative electroencephalography (qEEG) offers a non-invasive and cost-effective alternative for assessing neurophysiological changes associated with AD. This review critically evaluates current evidence on EEG biomarkers, including spectral, connectivity, and complexity measures, discussing their pathophysiological basis, diagnostic accuracy, and clinical utility in AD. Limitations and future perspectives, especially in developing standardized protocols and integrating machine learning techniques, are also addressed. |
| format | Article |
| id | doaj-art-a3d806e24be847e1b88ba4d19f63d946 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-a3d806e24be847e1b88ba4d19f63d9462025-08-20T04:00:50ZengMDPI AGDiagnostics2075-44182025-08-011515196510.3390/diagnostics15151965The Role of Quantitative EEG in the Diagnosis of Alzheimer’s DiseaseVasileios Papaliagkas0Department of Biomedical Sciences, International Hellenic University, 57400 Thessaloniki, GreeceAlzheimer’s disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline and functional impairment. Although advanced neuroimaging and cerebrospinal fluid biomarkers have improved early detection, their high costs, invasiveness, and limited accessibility restrict universal screening. Quantitative electroencephalography (qEEG) offers a non-invasive and cost-effective alternative for assessing neurophysiological changes associated with AD. This review critically evaluates current evidence on EEG biomarkers, including spectral, connectivity, and complexity measures, discussing their pathophysiological basis, diagnostic accuracy, and clinical utility in AD. Limitations and future perspectives, especially in developing standardized protocols and integrating machine learning techniques, are also addressed.https://www.mdpi.com/2075-4418/15/15/1965qEEGspectral analysisAlzheimer’s disease |
| spellingShingle | Vasileios Papaliagkas The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease Diagnostics qEEG spectral analysis Alzheimer’s disease |
| title | The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease |
| title_full | The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease |
| title_fullStr | The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease |
| title_full_unstemmed | The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease |
| title_short | The Role of Quantitative EEG in the Diagnosis of Alzheimer’s Disease |
| title_sort | role of quantitative eeg in the diagnosis of alzheimer s disease |
| topic | qEEG spectral analysis Alzheimer’s disease |
| url | https://www.mdpi.com/2075-4418/15/15/1965 |
| work_keys_str_mv | AT vasileiospapaliagkas theroleofquantitativeeeginthediagnosisofalzheimersdisease AT vasileiospapaliagkas roleofquantitativeeeginthediagnosisofalzheimersdisease |