Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection
While the Banff classification dichotomizes kidney allograft rejection based on the localization of the cells in the different compartments of the cortical kidney tissue [schematically interstitium for T cell mediated rejection (TCMR) and glomerular and peritubular capillaries for antibody-mediated...
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| Format: | Article |
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Frontiers Media S.A.
2024-12-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13835/full |
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| author | George Terinte-Balcan George Terinte-Balcan George Terinte-Balcan Emilie Lebraud Julien Zuber Dany Anglicheau Dany Anglicheau Gener Ismail Gener Ismail Marion Rabant Marion Rabant |
| author_facet | George Terinte-Balcan George Terinte-Balcan George Terinte-Balcan Emilie Lebraud Julien Zuber Dany Anglicheau Dany Anglicheau Gener Ismail Gener Ismail Marion Rabant Marion Rabant |
| author_sort | George Terinte-Balcan |
| collection | DOAJ |
| description | While the Banff classification dichotomizes kidney allograft rejection based on the localization of the cells in the different compartments of the cortical kidney tissue [schematically interstitium for T cell mediated rejection (TCMR) and glomerular and peritubular capillaries for antibody-mediated rejection (AMR)], there is a growing evidences that subtyping the immune cells can help refine prognosis prediction and treatment tailoring, based on a better understanding of the pathophysiology of kidney allograft rejection. In the last few years, multiplex IF techniques and automatic counting systems as well as transcriptomics studies (bulk, single-cell and spatial techniques) have provided invaluable clues to further decipher the complex puzzle of rejection. In this review, we aim to better describe the inflammatory infiltrates that occur during the course of kidney transplant rejection (active AMR, chronic active AMR and acute and chronic active TCMR). We also discuss minor components of the inflammatory response (mastocytes, eosinophils, neutrophils, follicular dendritic cells). We conclude by discussing whether the over simplistic dichotomy between AMR and TCMR, currently used in clinical routine, remains relevant given the great diversity of immune actors involved in rejections. |
| format | Article |
| id | doaj-art-a3d5cc938d7f46efa7467129d597836a |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Transplant International |
| spelling | doaj-art-a3d5cc938d7f46efa7467129d597836a2024-12-11T04:11:10ZengFrontiers Media S.A.Transplant International1432-22772024-12-013710.3389/ti.2024.1383513835Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft RejectionGeorge Terinte-Balcan0George Terinte-Balcan1George Terinte-Balcan2Emilie Lebraud3Julien Zuber4Dany Anglicheau5Dany Anglicheau6Gener Ismail7Gener Ismail8Marion Rabant9Marion Rabant10Nephrology department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pathology, Necker-Enfants Malades Hospital, Assistance Publique—Hopitaux de Paris, Paris, FranceCentre National de la Recherche Scientifique (CNRS), Inserm U1151, Institut Necker-Enfants Malades, Université Paris Cité, Paris, FranceCentre National de la Recherche Scientifique (CNRS), Inserm U1151, Institut Necker-Enfants Malades, Université Paris Cité, Paris, FranceDepartment of Kidney and Metabolic Diseases, Transplantation and Clinical Immunology, Necker Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, FranceCentre National de la Recherche Scientifique (CNRS), Inserm U1151, Institut Necker-Enfants Malades, Université Paris Cité, Paris, FranceDepartment of Kidney and Metabolic Diseases, Transplantation and Clinical Immunology, Necker Hospital, Assistance Publique Hôpitaux de Paris (AP-HP), Paris, FranceNephrology department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Nephrology, Fundeni Clinical Institute, Bucharest, RomaniaDepartment of Pathology, Necker-Enfants Malades Hospital, Assistance Publique—Hopitaux de Paris, Paris, FranceCentre National de la Recherche Scientifique (CNRS), Inserm U1151, Institut Necker-Enfants Malades, Université Paris Cité, Paris, FranceWhile the Banff classification dichotomizes kidney allograft rejection based on the localization of the cells in the different compartments of the cortical kidney tissue [schematically interstitium for T cell mediated rejection (TCMR) and glomerular and peritubular capillaries for antibody-mediated rejection (AMR)], there is a growing evidences that subtyping the immune cells can help refine prognosis prediction and treatment tailoring, based on a better understanding of the pathophysiology of kidney allograft rejection. In the last few years, multiplex IF techniques and automatic counting systems as well as transcriptomics studies (bulk, single-cell and spatial techniques) have provided invaluable clues to further decipher the complex puzzle of rejection. In this review, we aim to better describe the inflammatory infiltrates that occur during the course of kidney transplant rejection (active AMR, chronic active AMR and acute and chronic active TCMR). We also discuss minor components of the inflammatory response (mastocytes, eosinophils, neutrophils, follicular dendritic cells). We conclude by discussing whether the over simplistic dichotomy between AMR and TCMR, currently used in clinical routine, remains relevant given the great diversity of immune actors involved in rejections.https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13835/fullrejectionimmune cellsinfiltratesheterogeneitycomplexity |
| spellingShingle | George Terinte-Balcan George Terinte-Balcan George Terinte-Balcan Emilie Lebraud Julien Zuber Dany Anglicheau Dany Anglicheau Gener Ismail Gener Ismail Marion Rabant Marion Rabant Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection Transplant International rejection immune cells infiltrates heterogeneity complexity |
| title | Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection |
| title_full | Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection |
| title_fullStr | Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection |
| title_full_unstemmed | Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection |
| title_short | Deciphering the Complexity of the Immune Cell Landscape in Kidney Allograft Rejection |
| title_sort | deciphering the complexity of the immune cell landscape in kidney allograft rejection |
| topic | rejection immune cells infiltrates heterogeneity complexity |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13835/full |
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