Cellular senescence enhances adaptive anticancer immunosurveillance
Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neopla...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | OncoImmunology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2154115 |
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| _version_ | 1846102296407048192 |
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| author | Ines Marin Manuel Serrano Federico Pietrocola |
| author_facet | Ines Marin Manuel Serrano Federico Pietrocola |
| author_sort | Ines Marin |
| collection | DOAJ |
| description | Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8+ T cell-dependent anticancer effects when used as vaccination agents. |
| format | Article |
| id | doaj-art-a3d0e6213a2a4f6983c3b0cbc39a794b |
| institution | Kabale University |
| issn | 2162-402X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj-art-a3d0e6213a2a4f6983c3b0cbc39a794b2024-12-27T17:34:39ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2022.2154115Cellular senescence enhances adaptive anticancer immunosurveillanceInes Marin0Manuel Serrano1Federico Pietrocola2Aging and Metabolism Programme, Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, SpainAging and Metabolism Programme, Institute for Research in Biomedicine (IRB), Barcelona Institute of Science and Technology, Barcelona 08028, SpainDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge 14157, SwedenCancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8+ T cell-dependent anticancer effects when used as vaccination agents.https://www.tandfonline.com/doi/10.1080/2162402X.2022.2154115Aginginflammationinterferonimmunopeptidomevaccination |
| spellingShingle | Ines Marin Manuel Serrano Federico Pietrocola Cellular senescence enhances adaptive anticancer immunosurveillance OncoImmunology Aging inflammation interferon immunopeptidome vaccination |
| title | Cellular senescence enhances adaptive anticancer immunosurveillance |
| title_full | Cellular senescence enhances adaptive anticancer immunosurveillance |
| title_fullStr | Cellular senescence enhances adaptive anticancer immunosurveillance |
| title_full_unstemmed | Cellular senescence enhances adaptive anticancer immunosurveillance |
| title_short | Cellular senescence enhances adaptive anticancer immunosurveillance |
| title_sort | cellular senescence enhances adaptive anticancer immunosurveillance |
| topic | Aging inflammation interferon immunopeptidome vaccination |
| url | https://www.tandfonline.com/doi/10.1080/2162402X.2022.2154115 |
| work_keys_str_mv | AT inesmarin cellularsenescenceenhancesadaptiveanticancerimmunosurveillance AT manuelserrano cellularsenescenceenhancesadaptiveanticancerimmunosurveillance AT federicopietrocola cellularsenescenceenhancesadaptiveanticancerimmunosurveillance |