Constructing adverse outcome pathway for per- and polyfluoroalkyl substances and retinoblastoma based on PI3K-AKT/MAPK signaling pathway

BackgroundExposure to per- and polyfluoroalkyl substances (PFAS) is associated with various cancers, and recent studies suggest it may also increase the risk of retinoblastoma (RB) in newborns. However, the pathogenic mechanisms remain unclear. ObjectiveBy constructing an adverse outcome pathway (AO...

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Bibliographic Details
Main Authors: Yuyan GUI, Tingji WANG, Minghao WANG, Yaqi XU, Yunhui ZHANG
Format: Article
Language:English
Published: Editorial Committee of Journal of Environmental and Occupational Medicine 2024-12-01
Series:环境与职业医学
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Online Access:http://www.jeom.org/article/cn/10.11836/JEOM24387
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