Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability

Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability

Considering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective butyrylcholinesterase (BChE) inhibitors with exc...

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Bibliographic Details
Main Authors: Maja Sviben, Ilijana Odak, Danijela Barić, Milena Mlakić, Ottó Horváth, Lajos Fodor, Sunčica Roca, Ivana Šagud, Irena Škorić
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
ADMET
carbamates
butyrylcholinesterase inhibition
biometal complexation
docking
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/30/2/316
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