Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial
Introduction Infantile spasms (IS) is a type of severe epileptic encephalopathy that occurs in infancy and early childhood. IS is characterised clinically by epileptic spasms, often accompanied by sleep disorder and abnormal circadian rhythm. The endogenous circadian rhythm disorder, in turn, can ma...
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Main Authors: | Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou |
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Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2022-07-01
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Series: | BMJ Open |
Online Access: | https://bmjopen.bmj.com/content/12/7/e057970.full |
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