Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery

Artificial intelligence-driven rational design of ionizable lipids for mRNA delivery

Abstract Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial intelligence (AI) and virtual screening to...

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Bibliographic Details
Main Authors: Wei Wang, Kepan Chen, Ting Jiang, Yiyang Wu, Zheng Wu, Hang Ying, Hang Yu, Jing Lu, Jinzhong Lin, Defang Ouyang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55072-6
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