Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis
Abstract Because renal artery stenosis (RAS) often presents bilateral, we sought to investigate the renal pressure‐flow relationship and its relation to renin release, in the presence of a contralateral significant stenosis. A porcine model of graded unilateral RAS in the presence of a significant c...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70082 |
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| author | Benny Drieghe Gunther vanLoon Sabrina Stuyvaert Marc L. De Buyzere Thierry Bové Tine De Backer |
| author_facet | Benny Drieghe Gunther vanLoon Sabrina Stuyvaert Marc L. De Buyzere Thierry Bové Tine De Backer |
| author_sort | Benny Drieghe |
| collection | DOAJ |
| description | Abstract Because renal artery stenosis (RAS) often presents bilateral, we sought to investigate the renal pressure‐flow relationship and its relation to renin release, in the presence of a contralateral significant stenosis. A porcine model of graded unilateral RAS in the presence of a significant contralateral stenosis was created. The severity of the stenosis was expressed as the ratio between distal renal pressure (Pd) and aortic pressure (Pa). Pd and renal flow velocity were continuously measured using a combined pressure‐flow wire (Combowire®). Hemodynamic measurements and blood sampling for renin, angiotensin, and aldosterone were performed in baseline conditions and during progressive balloon inflation in the renal artery leading to stepwise 5% Pd decrements. Resistive index (RI) was computed as (1‐(End Diastolic V/Maximum Peak Systolic V))*100. A decrease of average peak flow velocity (APV) was observed when distal renal perfusion pressure decreased by 25% and was associated with activation of renin secretion. The RI decreased already for minimal changes in Pd/Pa ratio. In an animal model of unilateral graded RAS in the presence of a significant contralateral stenosis, a 25% decrease in perfusion pressure results in a significant decrease in distal renal flow, causing a more pronounced upregulation of renin secretion when compared to a model of graded unilateral RAS without contralateral significant RAS. |
| format | Article |
| id | doaj-art-a34eee5100584b45b48fb6c4db317116 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-a34eee5100584b45b48fb6c4db3171162025-01-10T11:14:29ZengWileyPhysiological Reports2051-817X2024-12-011223n/an/a10.14814/phy2.70082Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosisBenny Drieghe0Gunther vanLoon1Sabrina Stuyvaert2Marc L. De Buyzere3Thierry Bové4Tine De Backer5Heart Center University Hospital Ghent Ghent BelgiumDept of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University Ghent BelgiumDept of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University Ghent BelgiumHeart Center University Hospital Ghent Ghent BelgiumHeart Center University Hospital Ghent Ghent BelgiumHeart Center University Hospital Ghent Ghent BelgiumAbstract Because renal artery stenosis (RAS) often presents bilateral, we sought to investigate the renal pressure‐flow relationship and its relation to renin release, in the presence of a contralateral significant stenosis. A porcine model of graded unilateral RAS in the presence of a significant contralateral stenosis was created. The severity of the stenosis was expressed as the ratio between distal renal pressure (Pd) and aortic pressure (Pa). Pd and renal flow velocity were continuously measured using a combined pressure‐flow wire (Combowire®). Hemodynamic measurements and blood sampling for renin, angiotensin, and aldosterone were performed in baseline conditions and during progressive balloon inflation in the renal artery leading to stepwise 5% Pd decrements. Resistive index (RI) was computed as (1‐(End Diastolic V/Maximum Peak Systolic V))*100. A decrease of average peak flow velocity (APV) was observed when distal renal perfusion pressure decreased by 25% and was associated with activation of renin secretion. The RI decreased already for minimal changes in Pd/Pa ratio. In an animal model of unilateral graded RAS in the presence of a significant contralateral stenosis, a 25% decrease in perfusion pressure results in a significant decrease in distal renal flow, causing a more pronounced upregulation of renin secretion when compared to a model of graded unilateral RAS without contralateral significant RAS.https://doi.org/10.14814/phy2.70082hemodynamic significancerenal artery stenosisrenin‐angiotensin‐aldosterone systemrenovascular hypertensiontransstenotic pressure gradient measurement |
| spellingShingle | Benny Drieghe Gunther vanLoon Sabrina Stuyvaert Marc L. De Buyzere Thierry Bové Tine De Backer Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis Physiological Reports hemodynamic significance renal artery stenosis renin‐angiotensin‐aldosterone system renovascular hypertension transstenotic pressure gradient measurement |
| title | Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| title_full | Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| title_fullStr | Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| title_full_unstemmed | Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| title_short | Renal pressure‐flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| title_sort | renal pressure flow relationship and renin activation in a porcine model comparing unilateral and bilateral renal artery stenosis |
| topic | hemodynamic significance renal artery stenosis renin‐angiotensin‐aldosterone system renovascular hypertension transstenotic pressure gradient measurement |
| url | https://doi.org/10.14814/phy2.70082 |
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