Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease

Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease

Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This stu...

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Main Authors: Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
NMDAR
GRIN2C
GluN2C
14-3-3
Online Access:https://doi.org/10.1186/s13195-024-01661-y
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