Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature
IntroductionUndifferentiated Nasopharyngeal carcinoma (UNPC) exhibits the highest loco-regional cervical lymph node recurrence among head and neck epithelial malignancies. Axillary lymph node recurrence in NPC is uncommon.Case descriptionA 44-year-old male presented with two-month history of painles...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1578547/full |
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| author | Houyem Mansouri Ines Zemni Samia Ben Hssine Sabrine Boukhris Leila Achouri Najet Mahjoub |
| author_facet | Houyem Mansouri Ines Zemni Samia Ben Hssine Sabrine Boukhris Leila Achouri Najet Mahjoub |
| author_sort | Houyem Mansouri |
| collection | DOAJ |
| description | IntroductionUndifferentiated Nasopharyngeal carcinoma (UNPC) exhibits the highest loco-regional cervical lymph node recurrence among head and neck epithelial malignancies. Axillary lymph node recurrence in NPC is uncommon.Case descriptionA 44-year-old male presented with two-month history of painless swelling of the right axilla. He was diagnosed with stage IVB UNPC three years and eight months previously and had undergone neoadjuvant chemotherapy, and concurrent chemo-radiotherapy. Biopsy of the axillary swelling revealed metastatic UNPC. The patient was treated with axillary lymph node dissection followed by chemotherapy, and right axillary radiotherapy. Currently, the patient has been disease free for 12 months.ConclusionTo our knowledge, this is the second reported case of UNPC with isolated axillary lymph node recurrence after remission, treated with axillary lymph node dissection, chemotherapy, and radiotherapy. This case highlights a rare pattern of metastasis and underscores the need for thorough investigations and imaging in the long-term follow-up of NPC. |
| format | Article |
| id | doaj-art-a32113d0f38041928de691237ac2cb15 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-a32113d0f38041928de691237ac2cb152025-08-20T03:07:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15785471578547Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literatureHouyem Mansouri0Ines Zemni1Samia Ben Hssine2Sabrine Boukhris3Leila Achouri4Najet Mahjoub5Department of Surgical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Jedouba, TunisiaDepartment of Surgical Oncology, Salah Azaiez Institute of Oncology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, TunisiaDepartment of Radiation Therapy, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Jedouba, TunisiaDepartment of Surgical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Jedouba, TunisiaDepartment of Surgical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Jedouba, TunisiaDepartment of Medical Oncology, Regional Hospital of Jendouba, Faculty of Medicine of Tunis, University of Tunis El Manar, Jedouba, TunisiaIntroductionUndifferentiated Nasopharyngeal carcinoma (UNPC) exhibits the highest loco-regional cervical lymph node recurrence among head and neck epithelial malignancies. Axillary lymph node recurrence in NPC is uncommon.Case descriptionA 44-year-old male presented with two-month history of painless swelling of the right axilla. He was diagnosed with stage IVB UNPC three years and eight months previously and had undergone neoadjuvant chemotherapy, and concurrent chemo-radiotherapy. Biopsy of the axillary swelling revealed metastatic UNPC. The patient was treated with axillary lymph node dissection followed by chemotherapy, and right axillary radiotherapy. Currently, the patient has been disease free for 12 months.ConclusionTo our knowledge, this is the second reported case of UNPC with isolated axillary lymph node recurrence after remission, treated with axillary lymph node dissection, chemotherapy, and radiotherapy. This case highlights a rare pattern of metastasis and underscores the need for thorough investigations and imaging in the long-term follow-up of NPC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1578547/fullrecurrenceradiotherapychemotherapynasopharyngeal carcinomaaxillary lymph node metastasis |
| spellingShingle | Houyem Mansouri Ines Zemni Samia Ben Hssine Sabrine Boukhris Leila Achouri Najet Mahjoub Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature Frontiers in Oncology recurrence radiotherapy chemotherapy nasopharyngeal carcinoma axillary lymph node metastasis |
| title | Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature |
| title_full | Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature |
| title_fullStr | Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature |
| title_full_unstemmed | Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature |
| title_short | Multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma: a case report and review of the literature |
| title_sort | multimodal management of solitary axillary lymph node metastasis from a recurrent nasopharyngeal undifferentiated carcinoma a case report and review of the literature |
| topic | recurrence radiotherapy chemotherapy nasopharyngeal carcinoma axillary lymph node metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1578547/full |
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