Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis

Integrated analysis of molecular and clinical features associated with overall survival in melanoma patients with brain metastasis

Abstract Melanoma brain metastases (MBMs) are diagnosed in up to 60% of metastatic melanoma patients. Previous studies have identified clinical factors that correlate with overall survival (OS) after MBM diagnosis. However, molecular and immune features associated with OS are poorly understood. An i...

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Main Authors: Swaminathan Kumar, Meredith S. Pelster, Merve Hasanov, Renato A. Guerrieri, Courtney W. Hudgens, Debora A. Ledesma, Fuchenchu Wang, Grant M. Fischer, Julie M. Simon, Lauren E. Haydu, Kalman V. Katlowitz, Y. N. Vashisht Gopal, Jennifer L. McQuade, Lawrence N. Kwong, Jason T. Huse, Alexander J. Lazar, Michael T. Tetzlaff, Jeffrey E. Gershenwald, Aron Y. Joon, Ken Chen, Ziyi Li, Prahlad T. Ram, Sherise D. Ferguson, Michael A. Davies
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-025-01978-1
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