Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.

Significant autonomic nervous system responses to a specific osteopathic intervention, the cranial vault hold (CVH), have recently been demonstrated in forehead skin blood volume changes, heart rate, and respiration frequencies. The specificity of the CVH-intervention-related autonomic responses yet...

Full description

Saved in:
Bibliographic Details
Main Authors: Micha Keller, Volker Perlitz, Holger Pelz, Stefan Borik, Ines Repik, Armin Geilgens, Birol Cotuk, Gero Müller, Klaus Mathiak, Johannes Mayer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0317300
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850190078984323072
author Micha Keller
Volker Perlitz
Holger Pelz
Stefan Borik
Ines Repik
Armin Geilgens
Birol Cotuk
Gero Müller
Klaus Mathiak
Johannes Mayer
author_facet Micha Keller
Volker Perlitz
Holger Pelz
Stefan Borik
Ines Repik
Armin Geilgens
Birol Cotuk
Gero Müller
Klaus Mathiak
Johannes Mayer
author_sort Micha Keller
collection DOAJ
description Significant autonomic nervous system responses to a specific osteopathic intervention, the cranial vault hold (CVH), have recently been demonstrated in forehead skin blood volume changes, heart rate, and respiration frequencies. The specificity of the CVH-intervention-related autonomic responses yet requires differentiation. Thus, we compared autonomic responses to CVH with responses to compression of the fourth ventricle (CV4) and to two corresponding SHAM conditions. Analysis of frequencies and amplitudes for changes in skin blood volume and respiration in low (LF; 0.05-0.12 Hz), intermediate (IM; 0.12-0.18 Hz), and high (HF; 0.18-0.4 Hz) frequency bands, and metrics of heartrate variability revealed significant decreases in LF range (from 0.12 to 0.10 Hz), increased LF and decreased IM durations, and increased skin blood volume amplitudes in response to CVH, but no significant skin blood volume responses to any of the control interventions. Ratio changes for respiration and skin blood volume frequencies approximately at 3:1 during CVH, remained unchanged in all other interventions. Heart rate decreased across conditions, indicating an increase in parasympathetic tone. This was also indicated by a significant increase in root mean of squared successive difference following CV4. We incurred that rhythmic response patterns in the LF and IM bands only appeared in CVH. This suggests specific physiological responses to CVH warranting further investigation by studying e.g., responses to CVH in physical or mental health disorders with autonomic involvement.
format Article
id doaj-art-a30aa0b3d97b48c095264c34a7a3d5b5
institution OA Journals
issn 1932-6203
language English
publishDate 2025-01-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS ONE
spelling doaj-art-a30aa0b3d97b48c095264c34a7a3d5b52025-08-20T02:15:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031730010.1371/journal.pone.0317300Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.Micha KellerVolker PerlitzHolger PelzStefan BorikInes RepikArmin GeilgensBirol CotukGero MüllerKlaus MathiakJohannes MayerSignificant autonomic nervous system responses to a specific osteopathic intervention, the cranial vault hold (CVH), have recently been demonstrated in forehead skin blood volume changes, heart rate, and respiration frequencies. The specificity of the CVH-intervention-related autonomic responses yet requires differentiation. Thus, we compared autonomic responses to CVH with responses to compression of the fourth ventricle (CV4) and to two corresponding SHAM conditions. Analysis of frequencies and amplitudes for changes in skin blood volume and respiration in low (LF; 0.05-0.12 Hz), intermediate (IM; 0.12-0.18 Hz), and high (HF; 0.18-0.4 Hz) frequency bands, and metrics of heartrate variability revealed significant decreases in LF range (from 0.12 to 0.10 Hz), increased LF and decreased IM durations, and increased skin blood volume amplitudes in response to CVH, but no significant skin blood volume responses to any of the control interventions. Ratio changes for respiration and skin blood volume frequencies approximately at 3:1 during CVH, remained unchanged in all other interventions. Heart rate decreased across conditions, indicating an increase in parasympathetic tone. This was also indicated by a significant increase in root mean of squared successive difference following CV4. We incurred that rhythmic response patterns in the LF and IM bands only appeared in CVH. This suggests specific physiological responses to CVH warranting further investigation by studying e.g., responses to CVH in physical or mental health disorders with autonomic involvement.https://doi.org/10.1371/journal.pone.0317300
spellingShingle Micha Keller
Volker Perlitz
Holger Pelz
Stefan Borik
Ines Repik
Armin Geilgens
Birol Cotuk
Gero Müller
Klaus Mathiak
Johannes Mayer
Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
PLoS ONE
title Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
title_full Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
title_fullStr Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
title_full_unstemmed Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
title_short Specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations: A controlled study.
title_sort specificity of cranial cutaneous manipulations in modulating autonomic nervous system responses and physiological oscillations a controlled study
url https://doi.org/10.1371/journal.pone.0317300
work_keys_str_mv AT michakeller specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT volkerperlitz specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT holgerpelz specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT stefanborik specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT inesrepik specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT armingeilgens specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT birolcotuk specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT geromuller specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT klausmathiak specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy
AT johannesmayer specificityofcranialcutaneousmanipulationsinmodulatingautonomicnervoussystemresponsesandphysiologicaloscillationsacontrolledstudy