AKR1B10 and digestive tumors development: a review
Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462174/full |
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| author | Yao Shen Ailin Qiu Xin Huang Xin Huang Xiaosha Wen Sundar Shehzadi Yan He Qian Hu Jian Zhang Dixian Luo Shenghui Yang Shenghui Yang |
| author_facet | Yao Shen Ailin Qiu Xin Huang Xin Huang Xiaosha Wen Sundar Shehzadi Yan He Qian Hu Jian Zhang Dixian Luo Shenghui Yang Shenghui Yang |
| author_sort | Yao Shen |
| collection | DOAJ |
| description | Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we review recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene. |
| format | Article |
| id | doaj-art-a2e6e3e18ed94d989288c5cfae34e8bb |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a2e6e3e18ed94d989288c5cfae34e8bb2024-12-16T05:10:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14621741462174AKR1B10 and digestive tumors development: a reviewYao Shen0Ailin Qiu1Xin Huang2Xin Huang3Xiaosha Wen4Sundar Shehzadi5Yan He6Qian Hu7Jian Zhang8Dixian Luo9Shenghui Yang10Shenghui Yang11Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaInstitute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaLaboratory Medicine Center, Shenzhen Luohu Hospital Group, the Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, ChinaFirst Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaLaboratory Medicine Center, Shenzhen Luohu Hospital Group, the Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, ChinaLaboratory Medicine Center, Shenzhen Luohu Hospital Group, the Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, ChinaInstitute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaInstitute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaMedical School, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaLaboratory Medicine Center, Shenzhen Luohu Hospital Group, the Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, ChinaMedical School, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Preventive Medicine, Medical School, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaAldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we review recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462174/fullAKR1B10metabolismmechanismsreviewdigestive system tumors |
| spellingShingle | Yao Shen Ailin Qiu Xin Huang Xin Huang Xiaosha Wen Sundar Shehzadi Yan He Qian Hu Jian Zhang Dixian Luo Shenghui Yang Shenghui Yang AKR1B10 and digestive tumors development: a review Frontiers in Immunology AKR1B10 metabolism mechanisms review digestive system tumors |
| title | AKR1B10 and digestive tumors development: a review |
| title_full | AKR1B10 and digestive tumors development: a review |
| title_fullStr | AKR1B10 and digestive tumors development: a review |
| title_full_unstemmed | AKR1B10 and digestive tumors development: a review |
| title_short | AKR1B10 and digestive tumors development: a review |
| title_sort | akr1b10 and digestive tumors development a review |
| topic | AKR1B10 metabolism mechanisms review digestive system tumors |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462174/full |
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