Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing
The preparation of sophisticated hierarchically structured and cytocompatible hydrogel scaffolds is presented. For this purpose, a photosensitive resin was developed, printability was evaluated, and the optimal conditions for 3D printing were investigated. The design and fabrication by additive manu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/10/12/761 |
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| author | Mauricio A. Sarabia-Vallejos Scarleth Romero De la Fuente Nicolás A. Cohn-Inostroza Claudio A. Terraza Juan Rodríguez-Hernández Carmen M. González-Henríquez |
| author_facet | Mauricio A. Sarabia-Vallejos Scarleth Romero De la Fuente Nicolás A. Cohn-Inostroza Claudio A. Terraza Juan Rodríguez-Hernández Carmen M. González-Henríquez |
| author_sort | Mauricio A. Sarabia-Vallejos |
| collection | DOAJ |
| description | The preparation of sophisticated hierarchically structured and cytocompatible hydrogel scaffolds is presented. For this purpose, a photosensitive resin was developed, printability was evaluated, and the optimal conditions for 3D printing were investigated. The design and fabrication by additive manufacturing of tailor-made porous scaffolds were combined with the formation of surface wrinkled micropatterns. This enabled the combination of micrometer-sized channels (100–200 microns) with microstructured wrinkled surfaces (1–3 μm wavelength). The internal pore structure was found to play a critical role in the mechanical properties. More precisely, the TPMS structure with a zero local curvature appears to be an excellent candidate for maintaining its mechanical resistance to compression stress, thus retaining its structural integrity upon large uniaxial deformations up to 70%. Finally, the washing conditions selected enabled us to produce noncytotoxic materials, as evidenced by experiments using AlamarBlue to follow the metabolic activity of the cells. |
| format | Article |
| id | doaj-art-a2e1cba1b0974230b150ece56888e32a |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-a2e1cba1b0974230b150ece56888e32a2024-12-27T14:27:47ZengMDPI AGGels2310-28612024-11-01101276110.3390/gels10120761Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light ProcessingMauricio A. Sarabia-Vallejos0Scarleth Romero De la Fuente1Nicolás A. Cohn-Inostroza2Claudio A. Terraza3Juan Rodríguez-Hernández4Carmen M. González-Henríquez5Facultad de Ingeniería, Arquitectura y Diseño, Universidad San Sebastián, Santiago 8420524, ChileDepartamento de Química, Facultad de Ciencias Naturales, Matemáticas y del Medio Ambiente, Universidad Tecnológica Metropolitana, Santiago 7800003, ChileInstituto Universitario de Investigación y Desarrollo Tecnológico (IDT), Ignacio Valdivieso 2409, Santiago 8940000, ChileResearch Laboratory for Organic Polymer (RLOP), Facultad de Química y Farmacia, Pontificia Universidad Católica de Chile, Santiago 7810000, ChilePolymer Functionalization Group, Departamento de Química Macromolecular Aplicada, Instituto de Ciencia y Tecnología de Polímeros-Consejo Superior de Investigaciones Científicas (ICTP-CSIC), 28006 Madrid, SpainDepartamento de Química, Facultad de Ciencias Naturales, Matemáticas y del Medio Ambiente, Universidad Tecnológica Metropolitana, Santiago 7800003, ChileThe preparation of sophisticated hierarchically structured and cytocompatible hydrogel scaffolds is presented. For this purpose, a photosensitive resin was developed, printability was evaluated, and the optimal conditions for 3D printing were investigated. The design and fabrication by additive manufacturing of tailor-made porous scaffolds were combined with the formation of surface wrinkled micropatterns. This enabled the combination of micrometer-sized channels (100–200 microns) with microstructured wrinkled surfaces (1–3 μm wavelength). The internal pore structure was found to play a critical role in the mechanical properties. More precisely, the TPMS structure with a zero local curvature appears to be an excellent candidate for maintaining its mechanical resistance to compression stress, thus retaining its structural integrity upon large uniaxial deformations up to 70%. Finally, the washing conditions selected enabled us to produce noncytotoxic materials, as evidenced by experiments using AlamarBlue to follow the metabolic activity of the cells.https://www.mdpi.com/2310-2861/10/12/7613D porous scaffoldsstereolithographywrinkled nonplanar surfaces |
| spellingShingle | Mauricio A. Sarabia-Vallejos Scarleth Romero De la Fuente Nicolás A. Cohn-Inostroza Claudio A. Terraza Juan Rodríguez-Hernández Carmen M. González-Henríquez Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing Gels 3D porous scaffolds stereolithography wrinkled nonplanar surfaces |
| title | Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing |
| title_full | Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing |
| title_fullStr | Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing |
| title_full_unstemmed | Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing |
| title_short | Development of Soft Wrinkled Micropatterns on the Surface of 3D-Printed Hydrogel-Based Scaffolds via High-Resolution Digital Light Processing |
| title_sort | development of soft wrinkled micropatterns on the surface of 3d printed hydrogel based scaffolds via high resolution digital light processing |
| topic | 3D porous scaffolds stereolithography wrinkled nonplanar surfaces |
| url | https://www.mdpi.com/2310-2861/10/12/761 |
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