Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study
Xin-Jie Zhu,1 Mei-Ping Lu,1 Ruo-Xi Chen,1 Ze-Fan Mao,1,2 Yi-Fan Yang,1,3 Jie Han,1,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Otorhinolaryngology, Jian...
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Dove Medical Press
2025-01-01
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| author | Zhu XJ Lu MP Chen RX Mao ZF Yang YF Han J Cheng L |
| author_facet | Zhu XJ Lu MP Chen RX Mao ZF Yang YF Han J Cheng L |
| author_sort | Zhu XJ |
| collection | DOAJ |
| description | Xin-Jie Zhu,1 Mei-Ping Lu,1 Ruo-Xi Chen,1 Ze-Fan Mao,1,2 Yi-Fan Yang,1,3 Jie Han,1,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Otorhinolaryngology, Jiangsu Province Official Hospital & Geriatric Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 4International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cnPurpose: Although periostin has recently emerged as a new mediator in chronic allergic diseases, particularly in upper airway disease, its significance as a biomarker for allergic rhinitis (AR) is still unclear. Therefore, we aimed to assess the potential of periostin as a novel candidate biomarker for diagnosing and assessing the severity of AR.Patients and Methods: A total of 40 patients with AR and 22 healthy controls, all aged over 18 years, were recruited for the study. Participants underwent examinations to assess serum levels of total IgE (tIgE), specific IgE (sIgE), periostin, and remodeling-related factors, as well as fractional exhaled nitric oxide (FeNO) and fractional nasal nitric oxide (FnNO). Additionally, clinical characteristics questionnaire and nasal function assessments were completed by AR patients.Results: The levels of serum periostin were significantly higher in patients with AR compared to healthy controls (Z=− 3.605, p< 0.001). There was a notable positive correlation between serum periostin and FeNO (r=0.398, p=0.012), FnNO (r=0.379, p=0.017), as well as the visual analogue scale (VAS) score for ocular tearing (r=0.351, p=0.026) in AR patients. Furthermore, the serum periostin levels were higher in moderate-to-severe AR compared to mild AR cases (Z=− 2.007, p=0.045). The level of serum periostin in AR patients showed a sequential increase corresponding to shortness of breath scores from 0 to 3 (Z=10.137, p=0.017). The predicted probability of serum periostin demonstrated moderate diagnostic accuracy in detecting AR (AUC=0.773, p< 0.001).Conclusion: Serum periostin shows potential as a candidate biomarker for detecting AR and can serve as a surrogate biomarker for assessing airway inflammation in AR patients.Keywords: allergic rhinitis, biomarkers, fractional exhaled nitric oxide, inflammation, periostin |
| format | Article |
| id | doaj-art-a2e15dd13a664b48ab87d22313e29a48 |
| institution | Kabale University |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Journal of Asthma and Allergy |
| spelling | doaj-art-a2e15dd13a664b48ab87d22313e29a482025-01-07T16:42:40ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-01-01Volume 1811299004Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot StudyZhu XJLu MPChen RXMao ZFYang YFHan JCheng LXin-Jie Zhu,1 Mei-Ping Lu,1 Ruo-Xi Chen,1 Ze-Fan Mao,1,2 Yi-Fan Yang,1,3 Jie Han,1,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Otorhinolaryngology, Jiangsu Province Official Hospital & Geriatric Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 4International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cnPurpose: Although periostin has recently emerged as a new mediator in chronic allergic diseases, particularly in upper airway disease, its significance as a biomarker for allergic rhinitis (AR) is still unclear. Therefore, we aimed to assess the potential of periostin as a novel candidate biomarker for diagnosing and assessing the severity of AR.Patients and Methods: A total of 40 patients with AR and 22 healthy controls, all aged over 18 years, were recruited for the study. Participants underwent examinations to assess serum levels of total IgE (tIgE), specific IgE (sIgE), periostin, and remodeling-related factors, as well as fractional exhaled nitric oxide (FeNO) and fractional nasal nitric oxide (FnNO). Additionally, clinical characteristics questionnaire and nasal function assessments were completed by AR patients.Results: The levels of serum periostin were significantly higher in patients with AR compared to healthy controls (Z=− 3.605, p< 0.001). There was a notable positive correlation between serum periostin and FeNO (r=0.398, p=0.012), FnNO (r=0.379, p=0.017), as well as the visual analogue scale (VAS) score for ocular tearing (r=0.351, p=0.026) in AR patients. Furthermore, the serum periostin levels were higher in moderate-to-severe AR compared to mild AR cases (Z=− 2.007, p=0.045). The level of serum periostin in AR patients showed a sequential increase corresponding to shortness of breath scores from 0 to 3 (Z=10.137, p=0.017). The predicted probability of serum periostin demonstrated moderate diagnostic accuracy in detecting AR (AUC=0.773, p< 0.001).Conclusion: Serum periostin shows potential as a candidate biomarker for detecting AR and can serve as a surrogate biomarker for assessing airway inflammation in AR patients.Keywords: allergic rhinitis, biomarkers, fractional exhaled nitric oxide, inflammation, periostinhttps://www.dovepress.com/serum-periostin-as-a-potential-biomarker-in-the-evaluation-of-allergic-peer-reviewed-fulltext-article-JAAallergic rhinitisbiomarkersfractional exhaled nitric oxideinflammationperiostin |
| spellingShingle | Zhu XJ Lu MP Chen RX Mao ZF Yang YF Han J Cheng L Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study Journal of Asthma and Allergy allergic rhinitis biomarkers fractional exhaled nitric oxide inflammation periostin |
| title | Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study |
| title_full | Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study |
| title_fullStr | Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study |
| title_full_unstemmed | Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study |
| title_short | Serum Periostin as a Potential Biomarker in the Evaluation of Allergic Rhinitis: A Pilot Study |
| title_sort | serum periostin as a potential biomarker in the evaluation of allergic rhinitis a pilot study |
| topic | allergic rhinitis biomarkers fractional exhaled nitric oxide inflammation periostin |
| url | https://www.dovepress.com/serum-periostin-as-a-potential-biomarker-in-the-evaluation-of-allergic-peer-reviewed-fulltext-article-JAA |
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