A translational review of hyperthermia biology

This review was written to be included in the Special Collection ‘Therapy Ultrasound: Medicine’s Swiss Army Knife?’ The purpose of this review is to provide basic presentation and interpretation of the fundamentals of hyperthermia biology, as it pertains to uses of therapeutic ultrasound. The fundam...

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Bibliographic Details
Main Author: Mark W. Dewhirst
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:International Journal of Hyperthermia
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/02656736.2024.2447952
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Summary:This review was written to be included in the Special Collection ‘Therapy Ultrasound: Medicine’s Swiss Army Knife?’ The purpose of this review is to provide basic presentation and interpretation of the fundamentals of hyperthermia biology, as it pertains to uses of therapeutic ultrasound. The fundamentals are presented but in the setting of a translational interpretation and a view toward the future. Subjects that require future research and development are highlighted. The effects of hyperthermia are time and temperature dependent. Because intra-tumoral temperatures are non-uniform in tumors, one has to account for differential biologic effects in different parts of a tumor that occur simultaneously during and after hyperthermia.
ISSN:0265-6736
1464-5157