Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach

Bacterial strain type and TEM-1 enzyme allele impact antibiotic susceptibility distribution in monoclonal populations: a single-cell droplet approach

Bacterial populations can display different susceptibilities to antibiotics among individual cells, even though they originate from the same parent cell. This variability can lead to treatment failure and the emergence of resistant bacteria. Understanding the factors influencing this variability is...

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Bibliographic Details
Main Authors: Shahab Shahryari, Shakeel Ahmad, Ilona Paulina Foik, Paweł Jankowski, Adam Samborski, Marcin Równicki, Shreyas Kandhadai Vasantham, Piotr Garstecki
Format: Article
Language:English
Published: The Royal Society 2025-07-01
Series:Royal Society Open Science
Subjects:
microfluidics
clonal heteroresistance
antibiotic resistance
TEM-1 beta-lactamase
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsos.242143
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