Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen
The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/576370 |
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| _version_ | 1849744379054391296 |
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| author | Rehab Abdeen Nehal Salahuddin |
| author_facet | Rehab Abdeen Nehal Salahuddin |
| author_sort | Rehab Abdeen |
| collection | DOAJ |
| description | The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod-CS/MMT steadily and was pH dependent. |
| format | Article |
| id | doaj-art-a2b64d3b5ef14596a7afc4fd7dd8a52b |
| institution | DOAJ |
| issn | 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-a2b64d3b5ef14596a7afc4fd7dd8a52b2025-08-20T03:19:57ZengWileyJournal of Chemistry2090-90712013-01-01201310.1155/2013/576370576370Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of IbuprofenRehab Abdeen0Nehal Salahuddin1Biology DepartmentDepartment of ChemistryThe present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod-CS/MMT steadily and was pH dependent.http://dx.doi.org/10.1155/2013/576370 |
| spellingShingle | Rehab Abdeen Nehal Salahuddin Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen Journal of Chemistry |
| title | Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen |
| title_full | Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen |
| title_fullStr | Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen |
| title_full_unstemmed | Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen |
| title_short | Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen |
| title_sort | modified chitosan clay nanocomposite as a drug delivery system intercalation and in vitro release of ibuprofen |
| url | http://dx.doi.org/10.1155/2013/576370 |
| work_keys_str_mv | AT rehababdeen modifiedchitosanclaynanocompositeasadrugdeliverysystemintercalationandinvitroreleaseofibuprofen AT nehalsalahuddin modifiedchitosanclaynanocompositeasadrugdeliverysystemintercalationandinvitroreleaseofibuprofen |