Clozapine-induced hypertension: A paradox
Clozapine is a second-generation antipsychotic agent, considered the drug of choice for treatment-resistant schizophrenia. While tachycardia and postural hypotension are common cardiovascular side effects, reports of new-onset persistently elevated blood pressure are rare. We present a case where cl...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Telangana Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/tjp.tjp_29_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556298035888128 |
|---|---|
| author | Hamza Hussain P. C. B. Gupta Rajeevi Keeta |
| author_facet | Hamza Hussain P. C. B. Gupta Rajeevi Keeta |
| author_sort | Hamza Hussain |
| collection | DOAJ |
| description | Clozapine is a second-generation antipsychotic agent, considered the drug of choice for treatment-resistant schizophrenia. While tachycardia and postural hypotension are common cardiovascular side effects, reports of new-onset persistently elevated blood pressure are rare. We present a case where clozapine initiation led to hypertension requiring pharmacological intervention. A 42-year-old female with no prior hypertension and normal baseline blood pressure developed high blood pressure (150/90 mmHg) on clozapine 50 mg/day. These findings were consistent on subsequent trials, necessitating the continuation of amlodipine alongside clozapine at a 100 mg dose to maintain blood pressure control. |
| format | Article |
| id | doaj-art-a2aca083e00341f091e2979fe49d14dd |
| institution | Kabale University |
| issn | 2772-8706 2455-8559 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Telangana Journal of Psychiatry |
| spelling | doaj-art-a2aca083e00341f091e2979fe49d14dd2025-01-07T10:02:21ZengWolters Kluwer Medknow PublicationsTelangana Journal of Psychiatry2772-87062455-85592024-12-0110219619810.4103/tjp.tjp_29_24Clozapine-induced hypertension: A paradoxHamza HussainP. C. B. GuptaRajeevi KeetaClozapine is a second-generation antipsychotic agent, considered the drug of choice for treatment-resistant schizophrenia. While tachycardia and postural hypotension are common cardiovascular side effects, reports of new-onset persistently elevated blood pressure are rare. We present a case where clozapine initiation led to hypertension requiring pharmacological intervention. A 42-year-old female with no prior hypertension and normal baseline blood pressure developed high blood pressure (150/90 mmHg) on clozapine 50 mg/day. These findings were consistent on subsequent trials, necessitating the continuation of amlodipine alongside clozapine at a 100 mg dose to maintain blood pressure control.https://journals.lww.com/10.4103/tjp.tjp_29_24antipsychoticsclozapinehypertension |
| spellingShingle | Hamza Hussain P. C. B. Gupta Rajeevi Keeta Clozapine-induced hypertension: A paradox Telangana Journal of Psychiatry antipsychotics clozapine hypertension |
| title | Clozapine-induced hypertension: A paradox |
| title_full | Clozapine-induced hypertension: A paradox |
| title_fullStr | Clozapine-induced hypertension: A paradox |
| title_full_unstemmed | Clozapine-induced hypertension: A paradox |
| title_short | Clozapine-induced hypertension: A paradox |
| title_sort | clozapine induced hypertension a paradox |
| topic | antipsychotics clozapine hypertension |
| url | https://journals.lww.com/10.4103/tjp.tjp_29_24 |
| work_keys_str_mv | AT hamzahussain clozapineinducedhypertensionaparadox AT pcbgupta clozapineinducedhypertensionaparadox AT rajeevikeeta clozapineinducedhypertensionaparadox |