Marburg virus reaches Rwanda: how close are we to a vaccine solution?

Marburg virus disease (MVD) is a highly virulent and often fatal disease caused by the Marburg virus, a member of the Filoviridae family, closely related to the Ebola virus. Historically, outbreaks have been sporadic but lethal across various African countries, with high case fatality rates (CFRs)....

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Main Authors: Olivier Sibomana, Clyde Moono Hakayuwa, Jildas Munyantore
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:International Journal of Infectious Diseases
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Online Access:http://www.sciencedirect.com/science/article/pii/S1201971224004466
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author Olivier Sibomana
Clyde Moono Hakayuwa
Jildas Munyantore
author_facet Olivier Sibomana
Clyde Moono Hakayuwa
Jildas Munyantore
author_sort Olivier Sibomana
collection DOAJ
description Marburg virus disease (MVD) is a highly virulent and often fatal disease caused by the Marburg virus, a member of the Filoviridae family, closely related to the Ebola virus. Historically, outbreaks have been sporadic but lethal across various African countries, with high case fatality rates (CFRs). In 2023, significant outbreaks occurred in Tanzania and Equatorial Guinea, with CFRs of 62.5% and 75%, respectively. In 2024, Rwanda faced its first outbreak, starting on September 27, 2024. By November 8, 2024, Rwanda had conducted 7,408 tests, confirming 66 cases, 15 of which were fatal, and 51 recoveries. Although no approved vaccine currently exists for MVD, global health authorities are prioritizing the development of effective vaccines. Drawing on insights from the rapid COVID-19 vaccine development, several promising candidates are under exploration, with the cAd3-MARV showing notable potential. This paper examines the current MVD outbreak in Rwanda and the progress toward developing a long-term vaccine solution.
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spelling doaj-art-a2a94011df2348058c17cf4ac66291892025-01-11T06:38:38ZengElsevierInternational Journal of Infectious Diseases1201-97122025-04-01153107371Marburg virus reaches Rwanda: how close are we to a vaccine solution?Olivier Sibomana0Clyde Moono Hakayuwa1Jildas Munyantore2Department of General Medicine and Surgery, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda; Corresponding author: Olivier Sibomana, Department of General Medicine and Surgery, College of Medicine and Health Sciences, University of Rwanda, KG 11 Ave, Kigali, Rwanda.Department of Public Health, Copperbelt University, Ndola, ZambiaDepartment of General Medicine and Surgery, College of Medicine and Health Sciences, University of Rwanda, Kigali, RwandaMarburg virus disease (MVD) is a highly virulent and often fatal disease caused by the Marburg virus, a member of the Filoviridae family, closely related to the Ebola virus. Historically, outbreaks have been sporadic but lethal across various African countries, with high case fatality rates (CFRs). In 2023, significant outbreaks occurred in Tanzania and Equatorial Guinea, with CFRs of 62.5% and 75%, respectively. In 2024, Rwanda faced its first outbreak, starting on September 27, 2024. By November 8, 2024, Rwanda had conducted 7,408 tests, confirming 66 cases, 15 of which were fatal, and 51 recoveries. Although no approved vaccine currently exists for MVD, global health authorities are prioritizing the development of effective vaccines. Drawing on insights from the rapid COVID-19 vaccine development, several promising candidates are under exploration, with the cAd3-MARV showing notable potential. This paper examines the current MVD outbreak in Rwanda and the progress toward developing a long-term vaccine solution.http://www.sciencedirect.com/science/article/pii/S1201971224004466MarburgOutbreaksVaccinesRwanda
spellingShingle Olivier Sibomana
Clyde Moono Hakayuwa
Jildas Munyantore
Marburg virus reaches Rwanda: how close are we to a vaccine solution?
International Journal of Infectious Diseases
Marburg
Outbreaks
Vaccines
Rwanda
title Marburg virus reaches Rwanda: how close are we to a vaccine solution?
title_full Marburg virus reaches Rwanda: how close are we to a vaccine solution?
title_fullStr Marburg virus reaches Rwanda: how close are we to a vaccine solution?
title_full_unstemmed Marburg virus reaches Rwanda: how close are we to a vaccine solution?
title_short Marburg virus reaches Rwanda: how close are we to a vaccine solution?
title_sort marburg virus reaches rwanda how close are we to a vaccine solution
topic Marburg
Outbreaks
Vaccines
Rwanda
url http://www.sciencedirect.com/science/article/pii/S1201971224004466
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AT clydemoonohakayuwa marburgvirusreachesrwandahowclosearewetoavaccinesolution
AT jildasmunyantore marburgvirusreachesrwandahowclosearewetoavaccinesolution