Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats
Lipopolysaccharide (LPS), known as a stimulant of inflammation, causes acute liver injury by inducing the production of inflammatory mediators and oxidative stress. The purpose of this study is to determine whether of a nonsteroidal anti–inflammatory drug (NSAID) Flunixin meglumine (FM) and herbal...
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Universidad del Zulia
2024-12-01
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| Series: | Revista Científica |
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| Online Access: | https://mail.produccioncientificaluz.org/index.php/cientifica/article/view/43156 |
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| author | Tuba Parlak Ak Burcu Gul Mine Yaman Ismail Seven Gurdal Dagoglu Huseyin Fatih Gul |
| author_facet | Tuba Parlak Ak Burcu Gul Mine Yaman Ismail Seven Gurdal Dagoglu Huseyin Fatih Gul |
| author_sort | Tuba Parlak Ak |
| collection | DOAJ |
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Lipopolysaccharide (LPS), known as a stimulant of inflammation, causes acute liver injury by inducing the production of inflammatory mediators and oxidative stress. The purpose of this study is to determine whether of a nonsteroidal anti–inflammatory drug (NSAID) Flunixin meglumine (FM) and herbal an medicine Ginkgo biloba L. extract (GBE) show antioxidative, anti–inflammatory or antiapoptotic effects in liver tissue in LPS–induced hepatotoxicity. Animals were separated to 6 groups as control, sepsis (1 mg·kg-1, 7th day single dose, intraperitoneal (ip)), sepsis + FM (1 mg·kg-1, 7th day single dose, ip + 2.2 mg·kg-1 day, ip), sepsis + GBE (1 mg·kg-1, 7th day single dose, ip + 50 mg·kg-1 day, gavage), FM and GBE and the study continued for 7 days. Liver tissues taken from rats sacrificed were analyzed biochemically, histologically and immunohistochemically. Accordingly, LPS caused liver function markers alteration, inflammation, oxidative stress, and apoptosis, as well as histopathological changes in liver tissue. However, it was observed that LPS–induced changes were regulated by FM and GBE application. FM and GBE was demonstrated to have antioxidant, antiinflammatory and anti–apoptotic properties in LPS–induced hepatotoxicity.
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| format | Article |
| id | doaj-art-a2a76ed8b496493ca96fef8ca566220a |
| institution | Kabale University |
| issn | 0798-2259 2521-9715 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Universidad del Zulia |
| record_format | Article |
| series | Revista Científica |
| spelling | doaj-art-a2a76ed8b496493ca96fef8ca566220a2024-12-27T15:36:08ZengUniversidad del ZuliaRevista Científica0798-22592521-97152024-12-0134310.52973/rcfcv-e34501Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in ratsTuba Parlak Ak0Burcu Gul1Mine Yaman2Ismail Seven3Gurdal Dagoglu4Huseyin Fatih Gul5University of Munzur, Faculty of Health Sciences, Department of Nutrition and Dietetics.Tunceli, TürkiyeUniversity of Firat, Faculty of Health Sciences, Department of Nursing. Elazig, TürkiyeUniversity of Firat, Faculty of Veterinary Medicine, Department of Histology and Embryology. Elazig, TürkiyeUniversity of Firat, Vocational School of Sivrice, Department of Plant and Animal Production. Elazig, TürkiyeUniversity of Firat, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology. Elazig, TürkiyeUniversity of Kafkas, Faculty of Medicine, Department of Biochemistry. Kars, Türkiye Lipopolysaccharide (LPS), known as a stimulant of inflammation, causes acute liver injury by inducing the production of inflammatory mediators and oxidative stress. The purpose of this study is to determine whether of a nonsteroidal anti–inflammatory drug (NSAID) Flunixin meglumine (FM) and herbal an medicine Ginkgo biloba L. extract (GBE) show antioxidative, anti–inflammatory or antiapoptotic effects in liver tissue in LPS–induced hepatotoxicity. Animals were separated to 6 groups as control, sepsis (1 mg·kg-1, 7th day single dose, intraperitoneal (ip)), sepsis + FM (1 mg·kg-1, 7th day single dose, ip + 2.2 mg·kg-1 day, ip), sepsis + GBE (1 mg·kg-1, 7th day single dose, ip + 50 mg·kg-1 day, gavage), FM and GBE and the study continued for 7 days. Liver tissues taken from rats sacrificed were analyzed biochemically, histologically and immunohistochemically. Accordingly, LPS caused liver function markers alteration, inflammation, oxidative stress, and apoptosis, as well as histopathological changes in liver tissue. However, it was observed that LPS–induced changes were regulated by FM and GBE application. FM and GBE was demonstrated to have antioxidant, antiinflammatory and anti–apoptotic properties in LPS–induced hepatotoxicity. https://mail.produccioncientificaluz.org/index.php/cientifica/article/view/43156Flunixin meglumineGinkgo biloba L. extractliver damagesepsis |
| spellingShingle | Tuba Parlak Ak Burcu Gul Mine Yaman Ismail Seven Gurdal Dagoglu Huseyin Fatih Gul Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats Revista Científica Flunixin meglumine Ginkgo biloba L. extract liver damage sepsis |
| title | Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats |
| title_full | Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats |
| title_fullStr | Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats |
| title_full_unstemmed | Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats |
| title_short | Ginkgo biloba L. extract and flunixin meglumine attenuate sepsis–associated liver injury, oxidative stress, inflammation and apoptosis in rats |
| title_sort | ginkgo biloba l extract and flunixin meglumine attenuate sepsis associated liver injury oxidative stress inflammation and apoptosis in rats |
| topic | Flunixin meglumine Ginkgo biloba L. extract liver damage sepsis |
| url | https://mail.produccioncientificaluz.org/index.php/cientifica/article/view/43156 |
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