Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications
The Neural Crest cells are multipotent progenitor cells formed at the neural plate border that differentiate and give rise to a wide range of cell types and organs. Directional migration of NC cells and their correct positioning at target sites are essential during embryonic development, and defects...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1457506/full |
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| author | Esteban Salinas Esteban Salinas Francis Ruano-Rivadeneira Juan Ignacio Leal Teresa Caprile Marcela Torrejón Cecilia Arriagada Cecilia Arriagada |
| author_facet | Esteban Salinas Esteban Salinas Francis Ruano-Rivadeneira Juan Ignacio Leal Teresa Caprile Marcela Torrejón Cecilia Arriagada Cecilia Arriagada |
| author_sort | Esteban Salinas |
| collection | DOAJ |
| description | The Neural Crest cells are multipotent progenitor cells formed at the neural plate border that differentiate and give rise to a wide range of cell types and organs. Directional migration of NC cells and their correct positioning at target sites are essential during embryonic development, and defects in these processes results in congenital diseases. The NC migration begins with the epithelial-mesenchymal transition and extracellular matrix remodeling. The main cellular mechanisms that sustain this migration include contact inhibition of locomotion, co-attraction, chemotaxis and mechanical cues from the surrounding environment, all regulated by proteins that orchestrate cell polarity and motility. In this review we highlight the molecular mechanisms involved in neural crest cell migration and polarity, focusing on the role of small GTPases, Heterotrimeric G proteins and planar cell polarity complex. Here, we also discuss different congenital diseases caused by altered NC cell migration. |
| format | Article |
| id | doaj-art-a2a04912cc5c497b9cca95f75d41061d |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-a2a04912cc5c497b9cca95f75d41061d2025-01-06T06:59:26ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.14575061457506Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implicationsEsteban Salinas0Esteban Salinas1Francis Ruano-Rivadeneira2Juan Ignacio Leal3Teresa Caprile4Marcela Torrejón5Cecilia Arriagada6Cecilia Arriagada7Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileDepartamento de Ciencias Biológicas y Químicas, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileDevelopmental Biology Laboratory 116, School of Biological Sciences, Faculty of Exact and Natural Sciences, Pontificia Universidad Católica del Ecuador, Quito, EcuadorLaboratory of Signaling and Development (LSD), Group for the Study of Developmental Processes (GDeP), Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, ChileLaboratory of Axonal Guidance, Group for the Study of Developmental Processes (GDeP), Department of Cellular Biology, Faculty of Biological Sciences, Universidad de Concepción, Concepción, ChileLaboratory of Signaling and Development (LSD), Group for the Study of Developmental Processes (GDeP), Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepción, Concepción, ChileCentro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileDepartamento de Ciencias Biológicas y Químicas, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, ChileThe Neural Crest cells are multipotent progenitor cells formed at the neural plate border that differentiate and give rise to a wide range of cell types and organs. Directional migration of NC cells and their correct positioning at target sites are essential during embryonic development, and defects in these processes results in congenital diseases. The NC migration begins with the epithelial-mesenchymal transition and extracellular matrix remodeling. The main cellular mechanisms that sustain this migration include contact inhibition of locomotion, co-attraction, chemotaxis and mechanical cues from the surrounding environment, all regulated by proteins that orchestrate cell polarity and motility. In this review we highlight the molecular mechanisms involved in neural crest cell migration and polarity, focusing on the role of small GTPases, Heterotrimeric G proteins and planar cell polarity complex. Here, we also discuss different congenital diseases caused by altered NC cell migration.https://www.frontiersin.org/articles/10.3389/fcell.2024.1457506/fullneural crest (NC)cell polaritycell migrationneural crest disordercell signaling |
| spellingShingle | Esteban Salinas Esteban Salinas Francis Ruano-Rivadeneira Juan Ignacio Leal Teresa Caprile Marcela Torrejón Cecilia Arriagada Cecilia Arriagada Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications Frontiers in Cell and Developmental Biology neural crest (NC) cell polarity cell migration neural crest disorder cell signaling |
| title | Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications |
| title_full | Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications |
| title_fullStr | Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications |
| title_full_unstemmed | Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications |
| title_short | Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications |
| title_sort | polarity and migration of cranial and cardiac neural crest cells underlying molecular mechanisms and disease implications |
| topic | neural crest (NC) cell polarity cell migration neural crest disorder cell signaling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1457506/full |
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