Comparative Efficacy of Twice and Thrice Daily Colistin Administration in Critically Ill Patients Battling Multi-Drug Resistant Gram-Negative Infections: An Observational Study

Comparative Efficacy of Twice and Thrice Daily Colistin Administration in Critically Ill Patients Battling Multi-Drug Resistant Gram-Negative Infections: An Observational Study

Introduction: Colistin, a polymyxin antibiotic often reserved for treatment of multidrug-resistant Gram-negative infections, exhibits a narrow therapeutic index. Careful consideration of the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of colistin is essential to maximize its efficac...

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Bibliographic Details
Main Authors: Mohammed Valiyakath Hydross1, Sameer Abdul Samad2, 5*, Mahesh Balakrishna Savitri3, Ashish Datt Upadhyay4
Format: Article
Language:English
Published: Pasteur Institute of Iran 2024-03-01
Series:Journal of Medical Microbiology and Infectious Diseases
Subjects:
multi-drug resistant gramnegative infections
colistin
dosage regimen
nephrotoxicity
acute kidney injury (aki) events
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