Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid
BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological tr...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1503648/full |
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| author | Caijuan Dong Caijuan Dong Jielu Liu Alessandro Quaranta Xu Jing Mu Nie Craig E. Wheelock Craig E. Wheelock Benjamin Murrell Jonathan M. Coquet Tim Melander Bowden Thomas Engstrand Mikael Adner |
| author_facet | Caijuan Dong Caijuan Dong Jielu Liu Alessandro Quaranta Xu Jing Mu Nie Craig E. Wheelock Craig E. Wheelock Benjamin Murrell Jonathan M. Coquet Tim Melander Bowden Thomas Engstrand Mikael Adner |
| author_sort | Caijuan Dong |
| collection | DOAJ |
| description | BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS. Polyvinylalcohol-carbazate (PVAC), a polymer that can bind endogenous aldehydes, neutralize oxidative stress and inhibit inflammatory factors, may be a potential treatment for ALI/ARDS.MethodsA hydrochloric acid (HCl) induced mouse model was employed to assess the effect of PVAC. The changes of lung mechanics, pulmonary edema, histology and immune cells, cytokines, and lipid mediators in bronchioalveolar lavage fluid (BALF) were investigated in HCl-challenged mice.ResultsIn the HCl model, PVAC administration alleviated airway hyperresponsiveness and improved pulmonary edema and damage. In addition, it decreased the recruitment of neutrophils to the lung, and inhibited the increase of IL-6, TNF-α and leukotriene B4.ConclusionThese data indicates that PVAC is a potential candidate for the treatment of ALI/ARDS induced by aspiration of gastric acid or for the control of “asthma-like” symptoms in patients with gastroesophageal reflux. |
| format | Article |
| id | doaj-art-a290dc59624043b59fa3c9ea08088dab |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-a290dc59624043b59fa3c9ea08088dab2024-11-21T04:37:13ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-11-011510.3389/fphar.2024.15036481503648Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acidCaijuan Dong0Caijuan Dong1Jielu Liu2Alessandro Quaranta3Xu Jing4Mu Nie5Craig E. Wheelock6Craig E. Wheelock7Benjamin Murrell8Jonathan M. Coquet9Tim Melander Bowden10Thomas Engstrand11Mikael Adner12Experimental Asthma and Allergy Research Unit, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiang Su, ChinaExperimental Asthma and Allergy Research Unit, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenUnit of Integrative Metabolomics, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenExperimental Asthma and Allergy Research Unit, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenUnit of Integrative Metabolomics, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, SwedenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenDepartment of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, SwedenDepartment of Molecular Medicine and Surgery, plastic surgery section, Karolinska University Hospital, Stockholm, SwedenExperimental Asthma and Allergy Research Unit, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, SwedenBackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS. Polyvinylalcohol-carbazate (PVAC), a polymer that can bind endogenous aldehydes, neutralize oxidative stress and inhibit inflammatory factors, may be a potential treatment for ALI/ARDS.MethodsA hydrochloric acid (HCl) induced mouse model was employed to assess the effect of PVAC. The changes of lung mechanics, pulmonary edema, histology and immune cells, cytokines, and lipid mediators in bronchioalveolar lavage fluid (BALF) were investigated in HCl-challenged mice.ResultsIn the HCl model, PVAC administration alleviated airway hyperresponsiveness and improved pulmonary edema and damage. In addition, it decreased the recruitment of neutrophils to the lung, and inhibited the increase of IL-6, TNF-α and leukotriene B4.ConclusionThese data indicates that PVAC is a potential candidate for the treatment of ALI/ARDS induced by aspiration of gastric acid or for the control of “asthma-like” symptoms in patients with gastroesophageal reflux.https://www.frontiersin.org/articles/10.3389/fphar.2024.1503648/fullacute respiratory distress syndromeaspiration pneumoniaoxidative stresspharmacological treatmentintranasal administration |
| spellingShingle | Caijuan Dong Caijuan Dong Jielu Liu Alessandro Quaranta Xu Jing Mu Nie Craig E. Wheelock Craig E. Wheelock Benjamin Murrell Jonathan M. Coquet Tim Melander Bowden Thomas Engstrand Mikael Adner Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid Frontiers in Pharmacology acute respiratory distress syndrome aspiration pneumonia oxidative stress pharmacological treatment intranasal administration |
| title | Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid |
| title_full | Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid |
| title_fullStr | Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid |
| title_full_unstemmed | Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid |
| title_short | Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid |
| title_sort | polyvinylalcohol carbazate mitigates acute lung injury caused by hydrochloric acid |
| topic | acute respiratory distress syndrome aspiration pneumonia oxidative stress pharmacological treatment intranasal administration |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1503648/full |
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