Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid

Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid

BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological tr...

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Main Authors: Caijuan Dong, Jielu Liu, Alessandro Quaranta, Xu Jing, Mu Nie, Craig E. Wheelock, Benjamin Murrell, Jonathan M. Coquet, Tim Melander Bowden, Thomas Engstrand, Mikael Adner
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
acute respiratory distress syndrome
aspiration pneumonia
oxidative stress
pharmacological treatment
intranasal administration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1503648/full
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Summary:BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS. Polyvinylalcohol-carbazate (PVAC), a polymer that can bind endogenous aldehydes, neutralize oxidative stress and inhibit inflammatory factors, may be a potential treatment for ALI/ARDS.MethodsA hydrochloric acid (HCl) induced mouse model was employed to assess the effect of PVAC. The changes of lung mechanics, pulmonary edema, histology and immune cells, cytokines, and lipid mediators in bronchioalveolar lavage fluid (BALF) were investigated in HCl-challenged mice.ResultsIn the HCl model, PVAC administration alleviated airway hyperresponsiveness and improved pulmonary edema and damage. In addition, it decreased the recruitment of neutrophils to the lung, and inhibited the increase of IL-6, TNF-α and leukotriene B4.ConclusionThese data indicates that PVAC is a potential candidate for the treatment of ALI/ARDS induced by aspiration of gastric acid or for the control of “asthma-like” symptoms in patients with gastroesophageal reflux.
ISSN:1663-9812

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