Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS‐Triggered Cross‐Linker Release

Targeted Analysis of Mitochondrial Protein Conformations and Interactions by Endogenous ROS‐Triggered Cross‐Linker Release

Abstract The study of in situ conformations and interactions of mitochondrial proteins plays a crucial role in understanding their biological functions. Current chemical cross‐linking mass spectrometry (CX‐MS) has difficulty in achieving in‐depth analysis of mitochondrial proteins for cells without...

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Bibliographic Details
Main Authors: Wen Zhou, Yuwan Chen, Wenxin Fu, Xinwei Li, Yufei Xia, Qun Zhao, Baofeng Zhao, Yukui Zhang, Kaiguang Yang, Lihua Zhang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cross‐linking mass spectrometry
mitochondria
nanoparticles
protein complexes
reactive oxygen species‐responsive
Online Access:https://doi.org/10.1002/advs.202408462
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