Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies

Targeting ATAD3A Phosphorylation Mediated by TBK1 Ameliorates Senescence‐Associated Pathologies

Abstract Targeting cellular senescence, one of the hallmarks of aging and aging‐related pathologies emerges as an effective strategy for anti‐aging and cancer chemotherapy. Here, a switch from TBK1‐OPTN axis to TBK1‐ATAD3A axis to promote cellular senescence is shown. Mechanically, TBK1 protein is a...

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Bibliographic Details
Main Authors: Yujiao He, Yanchen Liu, Mingyue Zheng, Yuxiu Zou, Mujie Huang, Linsheng Wang, Ge Gao, Zhongjun Zhou, Guoxiang Jin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
anti‐aging therapy
cellular senescence
chemotherapy
mitophagy
TBK1‐ATAD3A axis
Online Access:https://doi.org/10.1002/advs.202404109
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