Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection.

In the present study, we analyzed the functional profile of CD8+ T-cell responses directed against autologous transmitted/founder HIV-1 isolates during acute and early infection, and examined whether multifunctionality is required for selection of virus escape mutations. Seven anti-retroviral therap...

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Main Authors: Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K P Liu, Emma L Turnbull, Jesus F Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D Tomaras, Barton F Haynes, Clive M Gray, Persephone Borrow, Mario Roederer, Andrew J McMichael, Kent J Weinhold
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001273&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1001273&type=printable

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