Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast
Background: Accurate pathological diagnosis is crucial for further treatment and estimation of an outcome in cases of breast cancer. The cytologic grade may provide information about the aggressive behavior of the tumor, thus guiding optimal therapy with prognostic information. The widely used Notti...
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Gujarat Adani Institute of Medical Sciences
2025-01-01
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| Series: | GAIMS Journal of Medical Sciences |
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| Online Access: | https://gjms.gaims.ac.in/index.php/gjms/article/view/245/193 |
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| author | Saloni Singhla Varun Prasad Srijan Srivastav |
| author_facet | Saloni Singhla Varun Prasad Srijan Srivastav |
| author_sort | Saloni Singhla |
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| description | Background: Accurate pathological diagnosis is crucial for further treatment and estimation of an outcome in cases of breast cancer. The cytologic grade may provide information about the aggressive behavior of the tumor, thus guiding optimal therapy with prognostic information. The widely used Nottingham histologic grading method is a tumor grading system with strong prognostic connections.
Materials and Methods: This cross-sectional study was conducted over one year in the Department of Pathology in IGMC, Shimla. Our study aimed to determine the role of Robinson’s grading in cases of primary infiltrating ductal carcinoma, breast, on cytology, confirm and grade the tumor on histopathology, and find the concordance between cytologic and histologic grading.
Results: On comparing cytologic and histologic grading, 37(68.5%) cases were graded based on cytology, which is comparable to most of the published data. The cytohistologic correlation was maximum in cases of grade III tumors (80%), followed by grade II tumors (70.2%), and minimum with grade I tumors (58.3%).
Conclusions: In this era of neoadjuvant chemotherapy, FNAC reports in cases of breast cancer should be incorporated with grading for prognostication. Considering the present study's data and other comparative studies, it can be concluded that Robinson’s cytologic grading correlates reasonably well with the histologic grading system, especially the grade III tumors, and paves the way for recommending neoadjuvant chemotherapy. Cytologic grading correlates reasonably well with the histologic grading system, especially the grade III tumors, and paves the way for recommending neoadjuvant chemotherapy. |
| format | Article |
| id | doaj-art-a2238a81bb9445eca22b6bb2c6c4ed45 |
| institution | Kabale University |
| issn | 2583-1763 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Gujarat Adani Institute of Medical Sciences |
| record_format | Article |
| series | GAIMS Journal of Medical Sciences |
| spelling | doaj-art-a2238a81bb9445eca22b6bb2c6c4ed452025-01-11T04:10:35ZengGujarat Adani Institute of Medical SciencesGAIMS Journal of Medical Sciences2583-17632025-01-0151153160https://doi.org/10.5281/zenodo.14625480Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma BreastSaloni Singhla0Varun Prasad1Srijan Srivastav2Department of Pathology, Dr Lal PathLabs, Patiala, Punjab, IndiaDepartment of Anesthesia, Veer Chandra Singh Garhwali Government Institute of Medical Science and Research, Srinagar, Pauri Garhwal, UttarakhandDepartment of Pathology, Veer Chandra Singh Garhwali Government Institute of Medical Science and Research, Srinagar, Pauri Garhwal, UttarakhandBackground: Accurate pathological diagnosis is crucial for further treatment and estimation of an outcome in cases of breast cancer. The cytologic grade may provide information about the aggressive behavior of the tumor, thus guiding optimal therapy with prognostic information. The widely used Nottingham histologic grading method is a tumor grading system with strong prognostic connections. Materials and Methods: This cross-sectional study was conducted over one year in the Department of Pathology in IGMC, Shimla. Our study aimed to determine the role of Robinson’s grading in cases of primary infiltrating ductal carcinoma, breast, on cytology, confirm and grade the tumor on histopathology, and find the concordance between cytologic and histologic grading. Results: On comparing cytologic and histologic grading, 37(68.5%) cases were graded based on cytology, which is comparable to most of the published data. The cytohistologic correlation was maximum in cases of grade III tumors (80%), followed by grade II tumors (70.2%), and minimum with grade I tumors (58.3%). Conclusions: In this era of neoadjuvant chemotherapy, FNAC reports in cases of breast cancer should be incorporated with grading for prognostication. Considering the present study's data and other comparative studies, it can be concluded that Robinson’s cytologic grading correlates reasonably well with the histologic grading system, especially the grade III tumors, and paves the way for recommending neoadjuvant chemotherapy. Cytologic grading correlates reasonably well with the histologic grading system, especially the grade III tumors, and paves the way for recommending neoadjuvant chemotherapy.https://gjms.gaims.ac.in/index.php/gjms/article/view/245/193breastinvasive ductal carcinomahistologycytology |
| spellingShingle | Saloni Singhla Varun Prasad Srijan Srivastav Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast GAIMS Journal of Medical Sciences breast invasive ductal carcinoma histology cytology |
| title | Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast |
| title_full | Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast |
| title_fullStr | Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast |
| title_full_unstemmed | Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast |
| title_short | Comparative Evaluation of Cytologic and Histologic Grading in Invasive Ductal Carcinoma Breast |
| title_sort | comparative evaluation of cytologic and histologic grading in invasive ductal carcinoma breast |
| topic | breast invasive ductal carcinoma histology cytology |
| url | https://gjms.gaims.ac.in/index.php/gjms/article/view/245/193 |
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