Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance
Objective: To understand whether TSH suppressive therapy affect short-term postoperative cancer-related depression and anxiety among DTC patients. To evaluate short-term postoperative psychological problems and its relationship with baseline parameters, fatigue, sleep quality, illness perception, an...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2024/1717119 |
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| author | Lin Chen Ningning Ren Qing Yang Xingsong Tian |
| author_facet | Lin Chen Ningning Ren Qing Yang Xingsong Tian |
| author_sort | Lin Chen |
| collection | DOAJ |
| description | Objective: To understand whether TSH suppressive therapy affect short-term postoperative cancer-related depression and anxiety among DTC patients. To evaluate short-term postoperative psychological problems and its relationship with baseline parameters, fatigue, sleep quality, illness perception, and patients’ quality of life. Study Design and Methods: This was a prospective, observational, single center study. This study involved 831 TC patients who consecutively admitted to the inpatient department of hospital between 1st June 2020 and 31th February 2021. Results: Mean scores of the self-rated anxiety scale (SAS) (49.04 vs. 40.69) and self-rated depression scale (SDS) (44.61 vs. 39.86), as well as the incidence of anxiety (41.5% vs. 22.1%) and depression (22.5% vs. 2.4%) significantly decreased 3 months after surgery. For personal and clinical characteristics, low educational background (SAS, β = 1.392; SDS, β = 1.622; and p<0.05), without children (SAS, β = 4.068; SDS, β = 1.873, and p<0.01), FNAC (SAS, β = −0.981; SDS, β = −2.583; and p<0.05), and multifocal tumor (SAS, β = −1.287; SDS, β = −2.681; and p<0.05) were the main effects for both short-term postoperative anxiety and depression. Multiple linear regression analysis identified the serum TSH level as a significant variable associated with worse SAS (Beta = −0.695 and p=0.043) and SDS (Beta = −3.133 and p<0.001) scores 3 months after surgery. FT4 was independently associated with SAS scores (Beta = −0.202 and p<0.001). Patients with middle ATA risk had a significantly higher level of SDS scores (p=0.033). Conclusion: We confirmed that cancer-related anxiety and depression among DTC patients significantly alleviated 3 months after surgery. TSH suppression therapy has profound effects on cancer-related anxiety and depression, and the degree of anxiety and depression significantly deteriorated with the decrease of TSH level. |
| format | Article |
| id | doaj-art-a219feab8221402b8a5fbdeaba3b6ae4 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a219feab8221402b8a5fbdeaba3b6ae42024-12-02T07:51:23ZengWileyInternational Journal of Endocrinology1687-83452024-01-01202410.1155/2024/1717119Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho RelevanceLin Chen0Ningning Ren1Qing Yang2Xingsong Tian3Shandong UniversityDepartment of Breast SurgeryShandong UniversityShandong UniversityObjective: To understand whether TSH suppressive therapy affect short-term postoperative cancer-related depression and anxiety among DTC patients. To evaluate short-term postoperative psychological problems and its relationship with baseline parameters, fatigue, sleep quality, illness perception, and patients’ quality of life. Study Design and Methods: This was a prospective, observational, single center study. This study involved 831 TC patients who consecutively admitted to the inpatient department of hospital between 1st June 2020 and 31th February 2021. Results: Mean scores of the self-rated anxiety scale (SAS) (49.04 vs. 40.69) and self-rated depression scale (SDS) (44.61 vs. 39.86), as well as the incidence of anxiety (41.5% vs. 22.1%) and depression (22.5% vs. 2.4%) significantly decreased 3 months after surgery. For personal and clinical characteristics, low educational background (SAS, β = 1.392; SDS, β = 1.622; and p<0.05), without children (SAS, β = 4.068; SDS, β = 1.873, and p<0.01), FNAC (SAS, β = −0.981; SDS, β = −2.583; and p<0.05), and multifocal tumor (SAS, β = −1.287; SDS, β = −2.681; and p<0.05) were the main effects for both short-term postoperative anxiety and depression. Multiple linear regression analysis identified the serum TSH level as a significant variable associated with worse SAS (Beta = −0.695 and p=0.043) and SDS (Beta = −3.133 and p<0.001) scores 3 months after surgery. FT4 was independently associated with SAS scores (Beta = −0.202 and p<0.001). Patients with middle ATA risk had a significantly higher level of SDS scores (p=0.033). Conclusion: We confirmed that cancer-related anxiety and depression among DTC patients significantly alleviated 3 months after surgery. TSH suppression therapy has profound effects on cancer-related anxiety and depression, and the degree of anxiety and depression significantly deteriorated with the decrease of TSH level.http://dx.doi.org/10.1155/2024/1717119 |
| spellingShingle | Lin Chen Ningning Ren Qing Yang Xingsong Tian Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance International Journal of Endocrinology |
| title | Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance |
| title_full | Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance |
| title_fullStr | Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance |
| title_full_unstemmed | Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance |
| title_short | Short-Term Postoperative Depression and Anxiety in Patients with Differentiated Thyroid Carcinoma: Assessment of Potential Oncologic-Psycho Relevance |
| title_sort | short term postoperative depression and anxiety in patients with differentiated thyroid carcinoma assessment of potential oncologic psycho relevance |
| url | http://dx.doi.org/10.1155/2024/1717119 |
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