The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat
Exposure of organisms to extremely low-frequency electromagnetic field (ELF-EMF; 50 Hz) has been increasing in recent decades, which is connected with dynamic technological development. ELF-EMF is considered a stress factor and its effects on organisms are still being investigated. We aimed to deter...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024002454 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846151055090384896 |
|---|---|
| author | Angelika Klimek Hanna Kletkiewicz Agnieszka Siejka Joanna Wyszkowska Justyna Maliszewska Maciej Klimiuk Milena Jankowska Justyna Rogalska |
| author_facet | Angelika Klimek Hanna Kletkiewicz Agnieszka Siejka Joanna Wyszkowska Justyna Maliszewska Maciej Klimiuk Milena Jankowska Justyna Rogalska |
| author_sort | Angelika Klimek |
| collection | DOAJ |
| description | Exposure of organisms to extremely low-frequency electromagnetic field (ELF-EMF; 50 Hz) has been increasing in recent decades, which is connected with dynamic technological development. ELF-EMF is considered a stress factor and its effects on organisms are still being investigated. We aimed to determine its impact on the locus coeruleus–noradrenergic (LC-NA) system enabling adaptation to stressful conditions. For this purpose, we exposed rats to 50 Hz ELF-EMF of 1 and 7 mT, 1 h/day for 7 days. The procedure was repeated three times to examine the organism's adaptive capabilities. Subsequently, the concentration of adrenaline, noradrenaline and its metabolite MHPG as well as the expression of the β2-adrenergic receptor was assessed. After the end of each exposure, part of the animals were subjected to a behavioural test to assess the influence of repeated ELF-EMF exposure on stress response to subsequent stress factors. Our research proved that mechanisms underlying the effects of ELF-EMF on stress response include the LC-NA system. ELF-EMF of 1 mT induced adaptive changes in the NA-LC system. However, exposure to 7 mT caused increased activity of the stress system which resulted in sensitization to subsequent, heterotypic (different from the one previously acting) stress factor. As ELF-EMF of 7 mT caused a profound decrease in β2-AR level would strongly inhibit the potential for neuroplastic processes in the hippocampus. Moreover, rats exposed to ELF-EMF of 7 mT showed moderately increased anxiety-related behaviour. Disturbances in NA-LC transmission may underlie the development of some neurodegenerative and psychiatric diseases which indicates the possible involvement of ELF-EMF in the pathogenesis of these disorders. |
| format | Article |
| id | doaj-art-a217b87faa964a79a0a4c3e13e19e50c |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-a217b87faa964a79a0a4c3e13e19e50c2024-11-28T04:34:03ZengElsevierBrain Research Bulletin1873-27472024-12-01219111111The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in ratAngelika Klimek0Hanna Kletkiewicz1Agnieszka Siejka2Joanna Wyszkowska3Justyna Maliszewska4Maciej Klimiuk5Milena Jankowska6Justyna Rogalska7Department of Exercise Physiology and Functional Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz 85-077, Poland; Correspondence to: Department of Exercise Physiology and Functional Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Świętojańska 20, Bydgoszcz 85-077, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, PolandDepartment of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University in Torun, 87-100, Poland; Correspondence to: Department of Animal Physiology and Neurobiology, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, Lwowska 1, Torun 87-100, PolandExposure of organisms to extremely low-frequency electromagnetic field (ELF-EMF; 50 Hz) has been increasing in recent decades, which is connected with dynamic technological development. ELF-EMF is considered a stress factor and its effects on organisms are still being investigated. We aimed to determine its impact on the locus coeruleus–noradrenergic (LC-NA) system enabling adaptation to stressful conditions. For this purpose, we exposed rats to 50 Hz ELF-EMF of 1 and 7 mT, 1 h/day for 7 days. The procedure was repeated three times to examine the organism's adaptive capabilities. Subsequently, the concentration of adrenaline, noradrenaline and its metabolite MHPG as well as the expression of the β2-adrenergic receptor was assessed. After the end of each exposure, part of the animals were subjected to a behavioural test to assess the influence of repeated ELF-EMF exposure on stress response to subsequent stress factors. Our research proved that mechanisms underlying the effects of ELF-EMF on stress response include the LC-NA system. ELF-EMF of 1 mT induced adaptive changes in the NA-LC system. However, exposure to 7 mT caused increased activity of the stress system which resulted in sensitization to subsequent, heterotypic (different from the one previously acting) stress factor. As ELF-EMF of 7 mT caused a profound decrease in β2-AR level would strongly inhibit the potential for neuroplastic processes in the hippocampus. Moreover, rats exposed to ELF-EMF of 7 mT showed moderately increased anxiety-related behaviour. Disturbances in NA-LC transmission may underlie the development of some neurodegenerative and psychiatric diseases which indicates the possible involvement of ELF-EMF in the pathogenesis of these disorders.http://www.sciencedirect.com/science/article/pii/S0361923024002454Extremely low-frequency electromagnetic fieldStress responseLocus coeruleusNoradrenalineβ2- adrenergic receptorHippocampus |
| spellingShingle | Angelika Klimek Hanna Kletkiewicz Agnieszka Siejka Joanna Wyszkowska Justyna Maliszewska Maciej Klimiuk Milena Jankowska Justyna Rogalska The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat Brain Research Bulletin Extremely low-frequency electromagnetic field Stress response Locus coeruleus Noradrenaline β2- adrenergic receptor Hippocampus |
| title | The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat |
| title_full | The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat |
| title_fullStr | The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat |
| title_full_unstemmed | The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat |
| title_short | The extremely low-frequency electromagnetic field (50 Hz) can establish a new “set-point” for the activity of the locus coeruleus–noradrenergic (LC-NA) system in rat |
| title_sort | extremely low frequency electromagnetic field 50 hz can establish a new set point for the activity of the locus coeruleus noradrenergic lc na system in rat |
| topic | Extremely low-frequency electromagnetic field Stress response Locus coeruleus Noradrenaline β2- adrenergic receptor Hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024002454 |
| work_keys_str_mv | AT angelikaklimek theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT hannakletkiewicz theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT agnieszkasiejka theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT joannawyszkowska theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT justynamaliszewska theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT maciejklimiuk theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT milenajankowska theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT justynarogalska theextremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT angelikaklimek extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT hannakletkiewicz extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT agnieszkasiejka extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT joannawyszkowska extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT justynamaliszewska extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT maciejklimiuk extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT milenajankowska extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat AT justynarogalska extremelylowfrequencyelectromagneticfield50hzcanestablishanewsetpointfortheactivityofthelocuscoeruleusnoradrenergiclcnasysteminrat |