Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy
The gastrointestinal system, often regarded as the 'second brain of humanity,' maintains a profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of gut microorganisms is paramount in the treatment of cerebral ailments. This review primarily focuses on biom...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-12-01
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| Series: | Nano TransMed |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676023000547 |
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| author | Ying Gong Zhijun Liu Piaopiao Zhou Jiahong Li Yang-Bao Miao |
| author_facet | Ying Gong Zhijun Liu Piaopiao Zhou Jiahong Li Yang-Bao Miao |
| author_sort | Ying Gong |
| collection | DOAJ |
| description | The gastrointestinal system, often regarded as the 'second brain of humanity,' maintains a profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of gut microorganisms is paramount in the treatment of cerebral ailments. This review primarily focuses on biomimetic precision nanocarriers, harnessing metabolites derived from the gut microbiota, to target brain disorders. Elaborating on the constituents, it illuminates the unique interplay between metabolites originating from the gut microbiota and the cerebral domain. Moreover, the review underscores the symbiotic relationship between nanocarriers fashioned from gut microbiota-derived metabolites and the augmentation of cerebral well-being. Offering a comprehensive outlook, this review sheds light on recent applications, challenges, and future prospects of nanocarriers rooted in metabolites derived from the gut microbiota across a spectrum of disease treatments. It presents an expansive perspective on the attributes of nanocarriers engineered from gut microbiota-derived metabolites, facilitating a deeper understanding of the intricate nexus between these metabolites and cerebral disorders. |
| format | Article |
| id | doaj-art-a211a3d9ffd04609aa45d02000958dd2 |
| institution | Kabale University |
| issn | 2790-6760 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-a211a3d9ffd04609aa45d02000958dd22024-11-12T05:22:07ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602023-12-0124100020Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapyYing Gong0Zhijun Liu1Piaopiao Zhou2Jiahong Li3Yang-Bao Miao4School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610041, ChinaUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, ChinaDepartment of Critical Care Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350108, ChinaSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610041, China; Corresponding authors.Department of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu 610000, China; Corresponding authors.The gastrointestinal system, often regarded as the 'second brain of humanity,' maintains a profound connection with the cerebral realm. Unlocking the intricate metabolic pathways of gut microorganisms is paramount in the treatment of cerebral ailments. This review primarily focuses on biomimetic precision nanocarriers, harnessing metabolites derived from the gut microbiota, to target brain disorders. Elaborating on the constituents, it illuminates the unique interplay between metabolites originating from the gut microbiota and the cerebral domain. Moreover, the review underscores the symbiotic relationship between nanocarriers fashioned from gut microbiota-derived metabolites and the augmentation of cerebral well-being. Offering a comprehensive outlook, this review sheds light on recent applications, challenges, and future prospects of nanocarriers rooted in metabolites derived from the gut microbiota across a spectrum of disease treatments. It presents an expansive perspective on the attributes of nanocarriers engineered from gut microbiota-derived metabolites, facilitating a deeper understanding of the intricate nexus between these metabolites and cerebral disorders.http://www.sciencedirect.com/science/article/pii/S2790676023000547NanocarrierMetabolitesGut to BrainVagus NerveImmune System |
| spellingShingle | Ying Gong Zhijun Liu Piaopiao Zhou Jiahong Li Yang-Bao Miao Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy Nano TransMed Nanocarrier Metabolites Gut to Brain Vagus Nerve Immune System |
| title | Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| title_full | Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| title_fullStr | Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| title_full_unstemmed | Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| title_short | Biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| title_sort | biomimetic nanocarriers harnessing microbial metabolites usher the path for brain disease therapy |
| topic | Nanocarrier Metabolites Gut to Brain Vagus Nerve Immune System |
| url | http://www.sciencedirect.com/science/article/pii/S2790676023000547 |
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