Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score
Abstract Background Recent studies have indicated that oxidative stress is a crucial pathophysiological process in glaucoma. We hypothesized that Posner-Schlossman syndrome (PSS) is a vascular inflammation in the ciliary body due to oxidative stress and endothelial dysfunction. Thus, we investigated...
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2024-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03814-x |
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| author | Fengping Zhao Changrong Lei Yue Zhang Shuangqing Wu Haishuang Lin De-fu Chen Chuanqi Lin Kun Xiong Mali Dai Shaodan Zhang Duo Li Yuanbo Liang |
| author_facet | Fengping Zhao Changrong Lei Yue Zhang Shuangqing Wu Haishuang Lin De-fu Chen Chuanqi Lin Kun Xiong Mali Dai Shaodan Zhang Duo Li Yuanbo Liang |
| author_sort | Fengping Zhao |
| collection | DOAJ |
| description | Abstract Background Recent studies have indicated that oxidative stress is a crucial pathophysiological process in glaucoma. We hypothesized that Posner-Schlossman syndrome (PSS) is a vascular inflammation in the ciliary body due to oxidative stress and endothelial dysfunction. Thus, we investigated serum uric acid (UA) and lipid levels in patients with refractory PSS with the aim of providing basic evidence for the mechanism of PSS. Methods This is a retrospective, case-control study. A total of 81 refractory PSS and 409 control participants were included in this study. Clinical and laboratory characteristics were reviewed using an electronic medical system. Propensity score-matched (PSM) analysis was performed to reduce demographic differences. The t-test, Mann-Whitney U test, and χ2 test were used to assess the differences between the PSS and control groups. Logistic regression analysis was used to identify the predictors of PSS. Results The higher serum UA (364.14 ± 98.72µmol/L vs. 322.38 ± 72.09µmol/L), higher low-density lipoprotein (LDL) / High-density lipoprotein (HDL) ratio (2.50 ± 0.97 vs. 1.95 ± 0.72) and lower HDL (1.29 ± 0.32 mmol/L vs. 1.59 ± 0.38 mmol/L) can be noticed in refractory PSS than control group. Logistics regression identified UA > 420 µmol/L (OR = 4.461) and the HDL < 1.03 mmol/L (OR = 3.896) were the independent risk factors for refractory PSS. Conclusions Increasing serum UA and decreasing HDL levels were positively correlated with the incidence risk of refractory PSS. Further prospective longitudinal studies and animal models are needed. |
| format | Article |
| id | doaj-art-a20f726f786b4dbcab2b83d484dcbd43 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-a20f726f786b4dbcab2b83d484dcbd432024-12-29T12:13:59ZengBMCBMC Ophthalmology1471-24152024-12-012411810.1186/s12886-024-03814-xAnalysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity scoreFengping Zhao0Changrong Lei1Yue Zhang2Shuangqing Wu3Haishuang Lin4De-fu Chen5Chuanqi Lin6Kun Xiong7Mali Dai8Shaodan Zhang9Duo Li10Yuanbo Liang11Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityDepartment of Nephrology, The First Affiliated Hospital of Wenzhou Medical UniversityEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical UniversityAbstract Background Recent studies have indicated that oxidative stress is a crucial pathophysiological process in glaucoma. We hypothesized that Posner-Schlossman syndrome (PSS) is a vascular inflammation in the ciliary body due to oxidative stress and endothelial dysfunction. Thus, we investigated serum uric acid (UA) and lipid levels in patients with refractory PSS with the aim of providing basic evidence for the mechanism of PSS. Methods This is a retrospective, case-control study. A total of 81 refractory PSS and 409 control participants were included in this study. Clinical and laboratory characteristics were reviewed using an electronic medical system. Propensity score-matched (PSM) analysis was performed to reduce demographic differences. The t-test, Mann-Whitney U test, and χ2 test were used to assess the differences between the PSS and control groups. Logistic regression analysis was used to identify the predictors of PSS. Results The higher serum UA (364.14 ± 98.72µmol/L vs. 322.38 ± 72.09µmol/L), higher low-density lipoprotein (LDL) / High-density lipoprotein (HDL) ratio (2.50 ± 0.97 vs. 1.95 ± 0.72) and lower HDL (1.29 ± 0.32 mmol/L vs. 1.59 ± 0.38 mmol/L) can be noticed in refractory PSS than control group. Logistics regression identified UA > 420 µmol/L (OR = 4.461) and the HDL < 1.03 mmol/L (OR = 3.896) were the independent risk factors for refractory PSS. Conclusions Increasing serum UA and decreasing HDL levels were positively correlated with the incidence risk of refractory PSS. Further prospective longitudinal studies and animal models are needed.https://doi.org/10.1186/s12886-024-03814-xUric acidHigh-density lipoproteinPosner-schlossman syndromeOxidative stressEndothelial dysfunctionGlaucoma |
| spellingShingle | Fengping Zhao Changrong Lei Yue Zhang Shuangqing Wu Haishuang Lin De-fu Chen Chuanqi Lin Kun Xiong Mali Dai Shaodan Zhang Duo Li Yuanbo Liang Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score BMC Ophthalmology Uric acid High-density lipoprotein Posner-schlossman syndrome Oxidative stress Endothelial dysfunction Glaucoma |
| title | Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score |
| title_full | Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score |
| title_fullStr | Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score |
| title_full_unstemmed | Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score |
| title_short | Analysis of uric acid and high-density lipoprotein levels in refractory posner-schlossman syndrome patients: a matched case-control study by the propensity score |
| title_sort | analysis of uric acid and high density lipoprotein levels in refractory posner schlossman syndrome patients a matched case control study by the propensity score |
| topic | Uric acid High-density lipoprotein Posner-schlossman syndrome Oxidative stress Endothelial dysfunction Glaucoma |
| url | https://doi.org/10.1186/s12886-024-03814-x |
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