LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen
This research was performed to evaluate the antioxidant and anti-inflammatory activities of ethanolic extract of Etlingera rubroloba AD stems and its metabolites. The IC50 values of antioxidant activity test of using ABTS and CUPRAC methods were 16.27 ± 0.23 μg/mL and 12.10 ± 0.32 μg/mL, respectivel...
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Elsevier
2024-12-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016424001749 |
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| author | Asriullah Jabbar Muhammad Ilyas Y Wahyuni Hasyrul Hamzah Anjar Windarsih Sylvia Utami Tunjung Pratiwi Abdul Rohman |
| author_facet | Asriullah Jabbar Muhammad Ilyas Y Wahyuni Hasyrul Hamzah Anjar Windarsih Sylvia Utami Tunjung Pratiwi Abdul Rohman |
| author_sort | Asriullah Jabbar |
| collection | DOAJ |
| description | This research was performed to evaluate the antioxidant and anti-inflammatory activities of ethanolic extract of Etlingera rubroloba AD stems and its metabolites. The IC50 values of antioxidant activity test of using ABTS and CUPRAC methods were 16.27 ± 0.23 μg/mL and 12.10 ± 0.32 μg/mL, respectively. The anti-inflammatory test (Interleukin 1β) of the ethanolic extract doses of 200, 300 and 400 mg/kg BW showed activities at concentration of 68.2, 32.42 and 25.31 ρg/mL, whereas Interleukin 12 activity test gave activity at concentrations of 869.99, 708.74 and 369.58 ρg/mL, respectively. The compound sinapyl alcohol acetate was firstly reported in ethanolic extract of E. rubroloba stem. |
| format | Article |
| id | doaj-art-a1fd152a48014cc992ce83e5ffced7e4 |
| institution | Kabale University |
| issn | 2666-0164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj-art-a1fd152a48014cc992ce83e5ffced7e42024-12-02T05:05:29ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642024-12-0110100780LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD PoulsenAsriullah Jabbar0Muhammad Ilyas Y1 Wahyuni2Hasyrul Hamzah3Anjar Windarsih4Sylvia Utami Tunjung Pratiwi5Abdul Rohman6Faculty of Pharmacy, Universitas Halu Oleo, Jl. HEA Mokodompit, Kendari, 93232, Indonesia; Indonesia Biofilm Research Collaboration Center (IBRCC), Jl. Farmako Sekip Utara, Yogyakarta, 55281, IndonesiaFaculty of Pharmacy, Universitas Halu Oleo, Jl. HEA Mokodompit, Kendari, 93232, Indonesia; Politeknik Bina Husada Kendari, 93117, IndonesiaFaculty of Pharmacy, Universitas Halu Oleo, Jl. HEA Mokodompit, Kendari, 93232, IndonesiaFaculty of Pharmacy, Universitas Muhammadiyah Kalimantan Timur, Samarinda, Kalimantan Timur, 75124, Indonesia; Indonesia Biofilm Research Collaboration Center (IBRCC), Jl. Farmako Sekip Utara, Yogyakarta, 55281, IndonesiaResearch Center for Food Technology and Processing (PRTPP), National Research and Innovation Agency (BRIN), Gunungkidul, Yogyakarta, 55861, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, 55281, Indonesia; Indonesia Biofilm Research Collaboration Center (IBRCC), Jl. Farmako Sekip Utara, Yogyakarta, 55281, IndonesiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, 55281, Indonesia; Research Centre of Halal Products, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, 55281, Indonesia; Corresponding author. Department of Pharmaceutical Chemistry, Universitas Gadjah Mada, Jl. Farmako Sekip Utara, Yogyakarta, 55281, Indonesia.This research was performed to evaluate the antioxidant and anti-inflammatory activities of ethanolic extract of Etlingera rubroloba AD stems and its metabolites. The IC50 values of antioxidant activity test of using ABTS and CUPRAC methods were 16.27 ± 0.23 μg/mL and 12.10 ± 0.32 μg/mL, respectively. The anti-inflammatory test (Interleukin 1β) of the ethanolic extract doses of 200, 300 and 400 mg/kg BW showed activities at concentration of 68.2, 32.42 and 25.31 ρg/mL, whereas Interleukin 12 activity test gave activity at concentrations of 869.99, 708.74 and 369.58 ρg/mL, respectively. The compound sinapyl alcohol acetate was firstly reported in ethanolic extract of E. rubroloba stem.http://www.sciencedirect.com/science/article/pii/S2666016424001749Etlingera rubrolobaLCMSABTSCUPRACAnti-inflamatorySinapyl alcohol acetate |
| spellingShingle | Asriullah Jabbar Muhammad Ilyas Y Wahyuni Hasyrul Hamzah Anjar Windarsih Sylvia Utami Tunjung Pratiwi Abdul Rohman LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen Case Studies in Chemical and Environmental Engineering Etlingera rubroloba LCMS ABTS CUPRAC Anti-inflamatory Sinapyl alcohol acetate |
| title | LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen |
| title_full | LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen |
| title_fullStr | LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen |
| title_full_unstemmed | LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen |
| title_short | LC-MS analysis, antioxidant and anti-inflamatory activity, isolation of secondary metabolite of ethanol extract stem of Etlingera rubroloba AD Poulsen |
| title_sort | lc ms analysis antioxidant and anti inflamatory activity isolation of secondary metabolite of ethanol extract stem of etlingera rubroloba ad poulsen |
| topic | Etlingera rubroloba LCMS ABTS CUPRAC Anti-inflamatory Sinapyl alcohol acetate |
| url | http://www.sciencedirect.com/science/article/pii/S2666016424001749 |
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