Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma
Background/Aim. Follicular lymphoma (FL) is a B-cell tumor usually with indolent clinical course, yet in some cases the course of the disease can be very aggressive. The aim of the re-search was to determine distribution of patients into prognostic groups based on the International Prognost...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500014S.pdf |
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| author | Simonović Olivera Mačukanović-Golubović Lana Anđelić Boško Antić Darko Mihaljević Biljana |
| author_facet | Simonović Olivera Mačukanović-Golubović Lana Anđelić Boško Antić Darko Mihaljević Biljana |
| author_sort | Simonović Olivera |
| collection | DOAJ |
| description | Background/Aim. Follicular lymphoma (FL) is a B-cell tumor usually with
indolent clinical course, yet in some cases the course of the disease can be
very aggressive. The aim of the re-search was to determine distribution of
patients into prognostic groups based on the International Prognostic Index
(IPI) and Folicular Lymphoma International Prognostic Index (FLIPI) criteria,
as well as to determine the importance of classifying patients into the
prognostic groups, since this could potentially have the influence on
selection of the treatment modality. Methods. The retrospective study was
performed on 257 patients with follicular lymphoma diagnosed between January
2000 and April 2011. Results. Based on the IPI score, 153 (59.53%) patients
had low risk, 57 (22.18%) low intermediate risk, 15 (5.84%) high intermediate
risk, 9 (3.50%) high risk, whereas the classification of 23 patients
diagnosed with FL remained with unknown risk according to the IPI. Based on
the FLIPI prognostic index, 113 (43.97%) patients had low risk, 70 (27.24%)
intermediate risk and 51 (19.84%) high risk, whereas the classification of 23
(8.95%) patients remained unknown. On the basis of the FLIPI 2 prognostic
index, 48 (18.68%) patients had low risk, 145 (56.42%) intermediate risk and
41 (15.95%) high risk. The classification into prognostic groups for 23
(8.95%) patients remained unknown. According to the IPI, FLIPI and FLIPI 2
there were the patients that required treatment in all the risk groups.
Conclusion. The FLIPI and FLIPI 2 effectively identify patients at high risk,
thus helping in treatment decision for each single patient. |
| format | Article |
| id | doaj-art-a1e9c29a5a7a441fb9f3d243b8ef0b7f |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-a1e9c29a5a7a441fb9f3d243b8ef0b7f2025-08-20T03:18:59ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502015-01-0172648348810.2298/VSP140115014S0042-84501500014SSerbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphomaSimonović Olivera0Mačukanović-Golubović Lana1Anđelić Boško2Antić Darko3Mihaljević Biljana4Clinical Center Niš, Clinic for Hematology and Clinical Immunology, NišClinical Center Niš, Clinic for Hematology and Clinical Immunology, Niš + Faculty of Medicine, NišClinical Center of Serbia, BelgradeClinical Center of Serbia, Belgrade + Faculty of Medicine, BelgradeClinical Center of Serbia, Belgrade + Faculty of Medicine, BelgradeBackground/Aim. Follicular lymphoma (FL) is a B-cell tumor usually with indolent clinical course, yet in some cases the course of the disease can be very aggressive. The aim of the re-search was to determine distribution of patients into prognostic groups based on the International Prognostic Index (IPI) and Folicular Lymphoma International Prognostic Index (FLIPI) criteria, as well as to determine the importance of classifying patients into the prognostic groups, since this could potentially have the influence on selection of the treatment modality. Methods. The retrospective study was performed on 257 patients with follicular lymphoma diagnosed between January 2000 and April 2011. Results. Based on the IPI score, 153 (59.53%) patients had low risk, 57 (22.18%) low intermediate risk, 15 (5.84%) high intermediate risk, 9 (3.50%) high risk, whereas the classification of 23 patients diagnosed with FL remained with unknown risk according to the IPI. Based on the FLIPI prognostic index, 113 (43.97%) patients had low risk, 70 (27.24%) intermediate risk and 51 (19.84%) high risk, whereas the classification of 23 (8.95%) patients remained unknown. On the basis of the FLIPI 2 prognostic index, 48 (18.68%) patients had low risk, 145 (56.42%) intermediate risk and 41 (15.95%) high risk. The classification into prognostic groups for 23 (8.95%) patients remained unknown. According to the IPI, FLIPI and FLIPI 2 there were the patients that required treatment in all the risk groups. Conclusion. The FLIPI and FLIPI 2 effectively identify patients at high risk, thus helping in treatment decision for each single patient.http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500014S.pdflymphoma, follicularSerbiapredictive value of testscombined modality therapy |
| spellingShingle | Simonović Olivera Mačukanović-Golubović Lana Anđelić Boško Antić Darko Mihaljević Biljana Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma Vojnosanitetski Pregled lymphoma, follicular Serbia predictive value of tests combined modality therapy |
| title | Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma |
| title_full | Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma |
| title_fullStr | Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma |
| title_full_unstemmed | Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma |
| title_short | Serbian lymphoma study group: Demografic characteristics of 257 patients with follicular lymphoma |
| title_sort | serbian lymphoma study group demografic characteristics of 257 patients with follicular lymphoma |
| topic | lymphoma, follicular Serbia predictive value of tests combined modality therapy |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500014S.pdf |
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