Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity
Nowadays, the overwhelmed global prevalence of obesity has been emerged as the main cause of chronic non-communicable diseases. Microbiome-derived short-chain fatty acids, particularly sodium butyrate (NaBu) has been presented a plethora of pharmacological features in the treatment of metabolic cond...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006480 |
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| author | Parichehr Amiri Seyed Ahmad Hosseini Maryam Saghafi-Asl Amin Akbari-Naserkiadeh Seyedeh Asal Jenani Zavieh Sara Arefhosseini Samira Asghari Neda Roshanravan |
| author_facet | Parichehr Amiri Seyed Ahmad Hosseini Maryam Saghafi-Asl Amin Akbari-Naserkiadeh Seyedeh Asal Jenani Zavieh Sara Arefhosseini Samira Asghari Neda Roshanravan |
| author_sort | Parichehr Amiri |
| collection | DOAJ |
| description | Nowadays, the overwhelmed global prevalence of obesity has been emerged as the main cause of chronic non-communicable diseases. Microbiome-derived short-chain fatty acids, particularly sodium butyrate (NaBu) has been presented a plethora of pharmacological features in the treatment of metabolic conditions. The present triple-blind, randomized clinical trial examined the effects of NaBu supplementation on the expression of lipid metabolism- related genes in peripheral blood mononuclear cells, body composition compartments and serum high-sensitivity C-reactive protein (hs-CRP) in subjects with obesity. Fifty obese subjects were randomly allocated into either NaBu (600 mg/day) or placebo (carboxymethyl cellulose 600 mg/day) group along with hypocaloric diet for 8 weeks. At the end of the trial, the mRNA expression levels of adiponectin receptor-1, adiponectin receptor-2 and uncoupling protein-3, significantly increased in NaBu group to almost two-fold higher levels, compared with placebo group (p = 0.030, p = 0.030 and p = 0.010, respectively). Moreover, body composition compartments improved significantly in NaBu arm, in terms of reductions in fat mass (p = 0.027) and visceral fat (p = 0.026) as well as increases in fat-free mass (p = 0.032). Serum hs-CRP levels markedly decreased in NaBu group, while inter-group differences were non-significant. Taken together, NaBu supplementation could exert favorable anti-obesity effects through molecular pathways, while further research is recommended.This study was registered in Iranian Registry of Clinical Trials (https://irct.behdasht.gov.ir/user/trial/56967/view), (IRCT20190303042905N3). |
| format | Article |
| id | doaj-art-a1e0c41bdb444458910233d823eb60f7 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-a1e0c41bdb444458910233d823eb60f72025-01-12T05:24:46ZengElsevierJournal of Functional Foods1756-46462025-01-01124106645Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesityParichehr Amiri0Seyed Ahmad Hosseini1Maryam Saghafi-Asl2Amin Akbari-Naserkiadeh3Seyedeh Asal Jenani Zavieh4Sara Arefhosseini5Samira Asghari6Neda Roshanravan7Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Nutrition and Metabolic Diseases Research Center, Clinical Research Institute, Ahvaz Jundishapur university of Medical Sciences, Ahvaz, IranNutrition and Metabolic Diseases Research Center, Clinical Research Institute, Ahvaz Jundishapur university of Medical Sciences, Ahvaz, Iran; Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61357-15794, Ahvaz, IranNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IranStem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author at: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Nowadays, the overwhelmed global prevalence of obesity has been emerged as the main cause of chronic non-communicable diseases. Microbiome-derived short-chain fatty acids, particularly sodium butyrate (NaBu) has been presented a plethora of pharmacological features in the treatment of metabolic conditions. The present triple-blind, randomized clinical trial examined the effects of NaBu supplementation on the expression of lipid metabolism- related genes in peripheral blood mononuclear cells, body composition compartments and serum high-sensitivity C-reactive protein (hs-CRP) in subjects with obesity. Fifty obese subjects were randomly allocated into either NaBu (600 mg/day) or placebo (carboxymethyl cellulose 600 mg/day) group along with hypocaloric diet for 8 weeks. At the end of the trial, the mRNA expression levels of adiponectin receptor-1, adiponectin receptor-2 and uncoupling protein-3, significantly increased in NaBu group to almost two-fold higher levels, compared with placebo group (p = 0.030, p = 0.030 and p = 0.010, respectively). Moreover, body composition compartments improved significantly in NaBu arm, in terms of reductions in fat mass (p = 0.027) and visceral fat (p = 0.026) as well as increases in fat-free mass (p = 0.032). Serum hs-CRP levels markedly decreased in NaBu group, while inter-group differences were non-significant. Taken together, NaBu supplementation could exert favorable anti-obesity effects through molecular pathways, while further research is recommended.This study was registered in Iranian Registry of Clinical Trials (https://irct.behdasht.gov.ir/user/trial/56967/view), (IRCT20190303042905N3).http://www.sciencedirect.com/science/article/pii/S1756464624006480Sodium butyrateObesityGene expressionBody compositionInflammation |
| spellingShingle | Parichehr Amiri Seyed Ahmad Hosseini Maryam Saghafi-Asl Amin Akbari-Naserkiadeh Seyedeh Asal Jenani Zavieh Sara Arefhosseini Samira Asghari Neda Roshanravan Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity Journal of Functional Foods Sodium butyrate Obesity Gene expression Body composition Inflammation |
| title | Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity |
| title_full | Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity |
| title_fullStr | Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity |
| title_full_unstemmed | Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity |
| title_short | Expression of lipid metabolism- related genes, body composition and inflammation: Effects of sodium butyrate supplementation in subjects with obesity |
| title_sort | expression of lipid metabolism related genes body composition and inflammation effects of sodium butyrate supplementation in subjects with obesity |
| topic | Sodium butyrate Obesity Gene expression Body composition Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006480 |
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