Influence of intranasal oxytocin on fear consolidation in healthy humans
Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin (OT) may facilitate extinction recall,to date, little is known about the effects of OT on memory consolidationprocesses.Aim To examine the effect of intranasal administration of OT compared with placebo...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-12-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/32/6/e100131.full |
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| _version_ | 1846173688827740160 |
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| author | Eric Bui Elizabeth Hoge Peter Rosencrans Scott Orr Rachel Ross Rebecca Ojserkis Naomi Simon |
| author_facet | Eric Bui Elizabeth Hoge Peter Rosencrans Scott Orr Rachel Ross Rebecca Ojserkis Naomi Simon |
| author_sort | Eric Bui |
| collection | DOAJ |
| description | Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin (OT) may facilitate extinction recall,to date, little is known about the effects of OT on memory consolidationprocesses.Aim To examine the effect of intranasal administration of OT compared with placebo on memory consolidation blockade of a de novo fear memory in a classical 2-day fear conditioning procedure.Results There were no significant differences between the OT and the placebo groups on the first two extinction trials (mean (SD)=0.01 (0.39) vs 0.15 (0.31), t=−1.092, p=0.28). Similarly, during early extinction, analysis of variance for repeated measures failed to show significant main effects of extinction trials: trials (F(4, 112)=1.58, p=0.18), drug (F(1, 112)=0.13, p=0.72) or drug × trials interaction (F(4, 112)=0.76, p=0.56).Conclusion Our results suggest that OT administered in a double-blind fashion immediately after fear conditioning does not significantly reduce consolidation of fear learning as measured by a differential skin conductance response tested at the beginning of extinction. |
| format | Article |
| id | doaj-art-a1d3977cf3b94bd8baccd6bb8a276c08 |
| institution | Kabale University |
| issn | 2517-729X |
| language | English |
| publishDate | 2019-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj-art-a1d3977cf3b94bd8baccd6bb8a276c082024-11-08T13:30:07ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2019-12-0132610.1136/gpsych-2019-100131Influence of intranasal oxytocin on fear consolidation in healthy humansEric Bui0Elizabeth Hoge1Peter Rosencrans2Scott Orr3Rachel Ross4Rebecca Ojserkis5Naomi Simon6Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United StatesDepartment of Psychiatry, Georgetown University Medical Center, Washington, District of Columbia, USAMassachusetts General Hospital, Boston, Massachusetts, USAMassachusetts General Hospital, Boston, Massachusetts, USAMassachusetts General Hospital, Boston, Massachusetts, USAMassachusetts General Hospital, Boston, Massachusetts, USANew York University Medical Center, New York, New York, USABackground Although recent data in healthy humans suggestthat treatment with intranasal oxytocin (OT) may facilitate extinction recall,to date, little is known about the effects of OT on memory consolidationprocesses.Aim To examine the effect of intranasal administration of OT compared with placebo on memory consolidation blockade of a de novo fear memory in a classical 2-day fear conditioning procedure.Results There were no significant differences between the OT and the placebo groups on the first two extinction trials (mean (SD)=0.01 (0.39) vs 0.15 (0.31), t=−1.092, p=0.28). Similarly, during early extinction, analysis of variance for repeated measures failed to show significant main effects of extinction trials: trials (F(4, 112)=1.58, p=0.18), drug (F(1, 112)=0.13, p=0.72) or drug × trials interaction (F(4, 112)=0.76, p=0.56).Conclusion Our results suggest that OT administered in a double-blind fashion immediately after fear conditioning does not significantly reduce consolidation of fear learning as measured by a differential skin conductance response tested at the beginning of extinction.https://gpsych.bmj.com/content/32/6/e100131.full |
| spellingShingle | Eric Bui Elizabeth Hoge Peter Rosencrans Scott Orr Rachel Ross Rebecca Ojserkis Naomi Simon Influence of intranasal oxytocin on fear consolidation in healthy humans General Psychiatry |
| title | Influence of intranasal oxytocin on fear consolidation in healthy humans |
| title_full | Influence of intranasal oxytocin on fear consolidation in healthy humans |
| title_fullStr | Influence of intranasal oxytocin on fear consolidation in healthy humans |
| title_full_unstemmed | Influence of intranasal oxytocin on fear consolidation in healthy humans |
| title_short | Influence of intranasal oxytocin on fear consolidation in healthy humans |
| title_sort | influence of intranasal oxytocin on fear consolidation in healthy humans |
| url | https://gpsych.bmj.com/content/32/6/e100131.full |
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