KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Abstract Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed i...

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Main Authors: Ouqiang Wu, Yuxin Jin, Zhiguang Zhang, Hao Zhou, Wenbin Xu, Linjie Chen, Morgan Jones, Kenny Yat Hong Kwan, Jianyuan Gao, Kai Zhang, Xiaofei Cheng, Qizhu Chen, Xinzhou Wang, Yan Michael Li, Zhenyu Guo, Jing Sun, Zhihua Chen, Bin Wang, Xiangyang Wang, Shuying Shen, Aimin Wu
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-024-00373-1
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