PET Imaging of Steroid Hormone Receptor Expression
Steroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, down-regulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers. These receptors act to induce tumor proliferation. In the imaging context, t...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2015.00026 |
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| _version_ | 1841561795838345216 |
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| author | Louis Allott Graham Smith Eric O. Aboagye Laurence Carroll |
| author_facet | Louis Allott Graham Smith Eric O. Aboagye Laurence Carroll |
| author_sort | Louis Allott |
| collection | DOAJ |
| description | Steroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, down-regulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers. These receptors act to induce tumor proliferation. In the imaging context, total expression together with modulation of expression can yield predictive and prognostic information. Currently, biopsy for histologic assessment of SHR expression is routine for breast and prostate cancer; however, the technique is not well suited to the heterogeneous tumor environment and can lead to incorrect receptor expression assignment, which precludes effective treatment. The development of positron emission tomography (PET) radioligands to image receptor expression may overcome the difficulties associated with tumor heterogeneity and facilitate the assessment of metastatic disease. |
| format | Article |
| id | doaj-art-a1abe55c2f0743a78cab6d065ba8083e |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-a1abe55c2f0743a78cab6d065ba8083e2025-01-03T01:24:46ZengSAGE PublishingMolecular Imaging1536-01212015-10-011410.2310/7290.2015.0002610.2310_7290.2015.00026PET Imaging of Steroid Hormone Receptor ExpressionLouis AllottGraham SmithEric O. AboagyeLaurence CarrollSteroid hormone receptor (SHR) expression and changes in SHR expression compared to basal levels, whether upregulated, down-regulated, or mutated, form a distinguishing feature of some breast, ovarian, and prostate cancers. These receptors act to induce tumor proliferation. In the imaging context, total expression together with modulation of expression can yield predictive and prognostic information. Currently, biopsy for histologic assessment of SHR expression is routine for breast and prostate cancer; however, the technique is not well suited to the heterogeneous tumor environment and can lead to incorrect receptor expression assignment, which precludes effective treatment. The development of positron emission tomography (PET) radioligands to image receptor expression may overcome the difficulties associated with tumor heterogeneity and facilitate the assessment of metastatic disease.https://doi.org/10.2310/7290.2015.00026 |
| spellingShingle | Louis Allott Graham Smith Eric O. Aboagye Laurence Carroll PET Imaging of Steroid Hormone Receptor Expression Molecular Imaging |
| title | PET Imaging of Steroid Hormone Receptor Expression |
| title_full | PET Imaging of Steroid Hormone Receptor Expression |
| title_fullStr | PET Imaging of Steroid Hormone Receptor Expression |
| title_full_unstemmed | PET Imaging of Steroid Hormone Receptor Expression |
| title_short | PET Imaging of Steroid Hormone Receptor Expression |
| title_sort | pet imaging of steroid hormone receptor expression |
| url | https://doi.org/10.2310/7290.2015.00026 |
| work_keys_str_mv | AT louisallott petimagingofsteroidhormonereceptorexpression AT grahamsmith petimagingofsteroidhormonereceptorexpression AT ericoaboagye petimagingofsteroidhormonereceptorexpression AT laurencecarroll petimagingofsteroidhormonereceptorexpression |