One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies
Abstract One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtain...
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Nature Portfolio
2025-08-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12997-2 |
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| author | Wiaam Al-Hasani Ruvini Ranasinghe Yip Han Chin Han Shi Jocelyn Chew Tina Mazahiri Nalinda Herath Fannie Lajeunesse-Trempe Pia Roser Starlene Grady Amy Lee Randolf Altmeyer Nicholas W. S. Chew Royce P. Vincent Shamsi El-Hasani Georgios K. Dimitriadis |
| author_facet | Wiaam Al-Hasani Ruvini Ranasinghe Yip Han Chin Han Shi Jocelyn Chew Tina Mazahiri Nalinda Herath Fannie Lajeunesse-Trempe Pia Roser Starlene Grady Amy Lee Randolf Altmeyer Nicholas W. S. Chew Royce P. Vincent Shamsi El-Hasani Georgios K. Dimitriadis |
| author_sort | Wiaam Al-Hasani |
| collection | DOAJ |
| description | Abstract One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtained 6,12 and 24 months postoperatively were compared with the pre-operative values using “Analyse-it software v5.40.2” and Graphpad Prism v9.3 for figures and tables. Data were tested for normality, described as Mean ± SD, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (CI). A significant body mass index (BMI), haemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) reduction was recorded throughout follow-up period, with greatest improvement seen 2 years after surgery (47.6 ± 22 kg/m2 vs. 29.4 ± 6.4 kg/m2 ,6.7 ± 1.8% vs. 5.5 ± 0.2% and 3.2 ± 1 vs. 2.05 + 0.7 mmol/ l, p < 0.05). The number of glucose-lowering drugs decreased from 1.6 ± 0.9 to 0.3 ± 0.4 at 24-months, p < 0.001. The rates for zinc, ferritin, folate, B12 and vitamin D deficiency at 24-months were: 8.9%,4%, 5.9%, 0% and 3% respectively. OAGB can effectively downstage obesity disease and improve glucose and lipid homeostasis with a low risk for nutritional deficiencies. This study is one of few to report specifically on the frequency and type of nutritional deficiencies following OAGB surgery. |
| format | Article |
| id | doaj-art-a1a4a0cd3cb04cbca919b11e7d728d5c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-a1a4a0cd3cb04cbca919b11e7d728d5c2025-08-20T03:47:07ZengNature PortfolioScientific Reports2045-23222025-08-0115111310.1038/s41598-025-12997-2One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficienciesWiaam Al-Hasani0Ruvini Ranasinghe1Yip Han Chin2Han Shi Jocelyn Chew3Tina Mazahiri4Nalinda Herath5Fannie Lajeunesse-Trempe6Pia Roser7Starlene Grady8Amy Lee9Randolf Altmeyer10Nicholas W. S. Chew11Royce P. Vincent12Shamsi El-Hasani13Georgios K. Dimitriadis14Department of Clinical Biochemistry, King’s College Hospital NHS Foundation TrustDepartment of Clinical Biochemistry, King’s College Hospital NHS Foundation TrustYong Loo Lin School of Medicine, National University of SingaporeAlice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Clinical Biochemistry, King’s College Hospital NHS Foundation TrustDepartment of Clinical Biochemistry, King’s College Hospital NHS Foundation TrustQuebec Heart and Lung Institute, Laval UniversitySchool of Life Course Sciences, King’s College LondonUpper GI Surgery & Bariatric Surgery, Princess Royal University HospitalUpper GI Surgery & Bariatric Surgery, Princess Royal University HospitalDepartment of Mathematics, Imperial College LondonYong Loo Lin School of Medicine, National University of SingaporeDepartment of Clinical Biochemistry, King’s College Hospital NHS Foundation TrustUpper GI Surgery & Bariatric Surgery, Princess Royal University HospitalDepartment of Endocrinology ASO/EASO COM, King’s College Hospital NHS Foundation TrustAbstract One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtained 6,12 and 24 months postoperatively were compared with the pre-operative values using “Analyse-it software v5.40.2” and Graphpad Prism v9.3 for figures and tables. Data were tested for normality, described as Mean ± SD, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (CI). A significant body mass index (BMI), haemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) reduction was recorded throughout follow-up period, with greatest improvement seen 2 years after surgery (47.6 ± 22 kg/m2 vs. 29.4 ± 6.4 kg/m2 ,6.7 ± 1.8% vs. 5.5 ± 0.2% and 3.2 ± 1 vs. 2.05 + 0.7 mmol/ l, p < 0.05). The number of glucose-lowering drugs decreased from 1.6 ± 0.9 to 0.3 ± 0.4 at 24-months, p < 0.001. The rates for zinc, ferritin, folate, B12 and vitamin D deficiency at 24-months were: 8.9%,4%, 5.9%, 0% and 3% respectively. OAGB can effectively downstage obesity disease and improve glucose and lipid homeostasis with a low risk for nutritional deficiencies. This study is one of few to report specifically on the frequency and type of nutritional deficiencies following OAGB surgery.https://doi.org/10.1038/s41598-025-12997-2One anastomosis gastric bypassBariatric surgeryNutritional deficiencyT2DMObesityHyperlipidaemia |
| spellingShingle | Wiaam Al-Hasani Ruvini Ranasinghe Yip Han Chin Han Shi Jocelyn Chew Tina Mazahiri Nalinda Herath Fannie Lajeunesse-Trempe Pia Roser Starlene Grady Amy Lee Randolf Altmeyer Nicholas W. S. Chew Royce P. Vincent Shamsi El-Hasani Georgios K. Dimitriadis One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies Scientific Reports One anastomosis gastric bypass Bariatric surgery Nutritional deficiency T2DM Obesity Hyperlipidaemia |
| title | One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| title_full | One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| title_fullStr | One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| title_full_unstemmed | One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| title_short | One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| title_sort | one anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies |
| topic | One anastomosis gastric bypass Bariatric surgery Nutritional deficiency T2DM Obesity Hyperlipidaemia |
| url | https://doi.org/10.1038/s41598-025-12997-2 |
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