One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies

One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies

Abstract One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtain...

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Main Authors: Wiaam Al-Hasani, Ruvini Ranasinghe, Yip Han Chin, Han Shi Jocelyn Chew, Tina Mazahiri, Nalinda Herath, Fannie Lajeunesse-Trempe, Pia Roser, Starlene Grady, Amy Lee, Randolf Altmeyer, Nicholas W. S. Chew, Royce P. Vincent, Shamsi El-Hasani, Georgios K. Dimitriadis
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
One anastomosis gastric bypass
Bariatric surgery
Nutritional deficiency
T2DM
Obesity
Hyperlipidaemia
Online Access:https://doi.org/10.1038/s41598-025-12997-2
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Summary:Abstract One anastomosis gastric bypass (OAGB) is a relatively novel bypass surgery variant, increasingly used as a primary surgical procedure. A total of 101 patients (mean age 44.7 ± 10.7 years, mean BMI 47.2 ± 6.6 kg/m2) underwent OAGB between 2014 and 2019 in a single institution. Results obtained 6,12 and 24 months postoperatively were compared with the pre-operative values using “Analyse-it software v5.40.2” and Graphpad Prism v9.3 for figures and tables. Data were tested for normality, described as Mean ± SD, compared using paired sample t-test with 5% p-value for significance and 95% confidence interval (CI). A significant body mass index (BMI), haemoglobin A1c (HbA1c) and low-density lipoprotein (LDL) reduction was recorded throughout follow-up period, with greatest improvement seen 2 years after surgery (47.6 ± 22 kg/m2 vs. 29.4 ± 6.4 kg/m2 ,6.7 ± 1.8% vs. 5.5 ± 0.2% and 3.2 ± 1 vs. 2.05 + 0.7 mmol/ l, p < 0.05). The number of glucose-lowering drugs decreased from 1.6 ± 0.9 to 0.3 ± 0.4 at 24-months, p < 0.001. The rates for zinc, ferritin, folate, B12 and vitamin D deficiency at 24-months were: 8.9%,4%, 5.9%, 0% and 3% respectively. OAGB can effectively downstage obesity disease and improve glucose and lipid homeostasis with a low risk for nutritional deficiencies. This study is one of few to report specifically on the frequency and type of nutritional deficiencies following OAGB surgery.
ISSN:2045-2322

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