The Influence of Topiramate on Morphine Dependence in Mice

The Influence of Topiramate on Morphine Dependence in Mice

Topiramate evokes pharmacological activity via a blockade of voltage-dependent sodium channels, reduction in glutamate release, inhibition of AMPA receptors and kainate receptors, and potentiation of GABAergic neurotransmission. Therefore, it is used not only as an antiseizure drug but is also effec...

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Main Authors: Adrian Pysiewicz, Antonina Mazur, Jolanta Kotlińska, Irena Baranowska-Bosiacka, Krzysztof Fronc, Małgorzata Łupina, Marta Kruk-Słomka, Joanna Listos
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
topiramate
morphine withdrawal signs
naloxone
morphine tolerance
hot-plate test
behavioral sensitization
Online Access:https://www.mdpi.com/2218-273X/15/5/730
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