Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits

Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits

Abstract Rare mutations in the gene encoding presenilin2 (PSEN2) are known to cause familial Alzheimer’s disease (FAD). Here, we explored how altered PSEN2 expression impacts on the amyloidosis, endolysosomal abnormalities, and synaptic dysfunction observed in female APP knock-in mice. We demonstrat...

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Main Authors: Anika Perdok, Zoë P. Van Acker, Céline Vrancx, Ragna Sannerud, Inge Vorsters, Assunta Verrengia, Zsuzsanna Callaerts-Végh, Eline Creemers, Sara Gutiérrez Fernández, Britt D’hauw, Lutgarde Serneels, Keimpe Wierda, Lucía Chávez-Gutiérrez, Wim Annaert
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54777-y
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