Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis
Cesium-137 (Cs-137) is a radioactive isotope present in marine environments due to the operation of nuclear power plants and weapons testing. Radiocesium poses a potential risk to marine life due to its long half-life and bioaccumulation. This study evaluated the genotoxicity of low doses of Cs-137...
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Elsevier
2024-10-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024155491 |
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| author | Yuttanagon Sookjuntra Wanwiwa Tumnoi Varalee Kongcharoen Chitsanupong Khrautongkieo Yutthana Tumnoi |
| author_facet | Yuttanagon Sookjuntra Wanwiwa Tumnoi Varalee Kongcharoen Chitsanupong Khrautongkieo Yutthana Tumnoi |
| author_sort | Yuttanagon Sookjuntra |
| collection | DOAJ |
| description | Cesium-137 (Cs-137) is a radioactive isotope present in marine environments due to the operation of nuclear power plants and weapons testing. Radiocesium poses a potential risk to marine life due to its long half-life and bioaccumulation. This study evaluated the genotoxicity of low doses of Cs-137 in the Asian green mussel Perna viridis, a sentinel species for marine pollution monitoring, by performing the comet assay and micronucleus test on hemolymph samples. Genotoxicity was assessed after exposing mussels to Cs-137 at dose rates of 0, 5, 10, and 15 μGy/h for 48 h. Cs-137's organ-specific distribution was also determined using HPGe gamma spectrometry. Even at low radiation doses, Cs-137 was found to exert genotoxic effects. Significant increases in DNA strand breaks (%Tail DNA) and micronucleus formation (MNF) were observed at all tested dose rates compared with the levels in controls, with dose-dependent responses. Cs-137 predominantly accumulated in the soft tissues, specifically the gills and digestive gland. The findings support the recommended safety level of 10 μGy/h for aquatic organisms, suggesting its appropriateness as a fundamental criterion for developing the national marine water quality standard for Cs-137 in Thailand. |
| format | Article |
| id | doaj-art-a19ffdedece84fdbb961ac576b47a19b |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a19ffdedece84fdbb961ac576b47a19b2024-11-12T05:20:52ZengElsevierHeliyon2405-84402024-10-011020e39518Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridisYuttanagon Sookjuntra0Wanwiwa Tumnoi1Varalee Kongcharoen2Chitsanupong Khrautongkieo3Yutthana Tumnoi4Environmental Assessment Research Unit, Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000, ThailandEnvironmental Assessment Research Unit, Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000, Thailand; Corresponding author.Safety Research and Development Section, Regulatory Technical Support Division, Office of Atoms for Peace, Bangkok, 10900, ThailandSafety Research and Development Section, Regulatory Technical Support Division, Office of Atoms for Peace, Bangkok, 10900, ThailandOffice of Atoms for Peace, Bangkok, 10900, ThailandCesium-137 (Cs-137) is a radioactive isotope present in marine environments due to the operation of nuclear power plants and weapons testing. Radiocesium poses a potential risk to marine life due to its long half-life and bioaccumulation. This study evaluated the genotoxicity of low doses of Cs-137 in the Asian green mussel Perna viridis, a sentinel species for marine pollution monitoring, by performing the comet assay and micronucleus test on hemolymph samples. Genotoxicity was assessed after exposing mussels to Cs-137 at dose rates of 0, 5, 10, and 15 μGy/h for 48 h. Cs-137's organ-specific distribution was also determined using HPGe gamma spectrometry. Even at low radiation doses, Cs-137 was found to exert genotoxic effects. Significant increases in DNA strand breaks (%Tail DNA) and micronucleus formation (MNF) were observed at all tested dose rates compared with the levels in controls, with dose-dependent responses. Cs-137 predominantly accumulated in the soft tissues, specifically the gills and digestive gland. The findings support the recommended safety level of 10 μGy/h for aquatic organisms, suggesting its appropriateness as a fundamental criterion for developing the national marine water quality standard for Cs-137 in Thailand.http://www.sciencedirect.com/science/article/pii/S2405844024155491BivalveChromosomal aberrationDNA damageRadiation doseRadionuclide |
| spellingShingle | Yuttanagon Sookjuntra Wanwiwa Tumnoi Varalee Kongcharoen Chitsanupong Khrautongkieo Yutthana Tumnoi Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis Heliyon Bivalve Chromosomal aberration DNA damage Radiation dose Radionuclide |
| title | Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis |
| title_full | Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis |
| title_fullStr | Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis |
| title_full_unstemmed | Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis |
| title_short | Low-level ionizing radiation-induced DNA responses in the Asian green mussel Perna viridis |
| title_sort | low level ionizing radiation induced dna responses in the asian green mussel perna viridis |
| topic | Bivalve Chromosomal aberration DNA damage Radiation dose Radionuclide |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024155491 |
| work_keys_str_mv | AT yuttanagonsookjuntra lowlevelionizingradiationinduceddnaresponsesintheasiangreenmusselpernaviridis AT wanwiwatumnoi lowlevelionizingradiationinduceddnaresponsesintheasiangreenmusselpernaviridis AT varaleekongcharoen lowlevelionizingradiationinduceddnaresponsesintheasiangreenmusselpernaviridis AT chitsanupongkhrautongkieo lowlevelionizingradiationinduceddnaresponsesintheasiangreenmusselpernaviridis AT yutthanatumnoi lowlevelionizingradiationinduceddnaresponsesintheasiangreenmusselpernaviridis |